======= FOS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOS
  * **<color #00a2e8>Official Name</color>**: Fos proto-oncogene, AP-1 transcription factor subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2353|2353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01100|P01100]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2.  These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.  As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.  In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 2|
|bZIP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription factor AP-1 complex|
|conditioned taste aversion|
|response to gravity|
|sleep|
|response to muscle stretch|
|response to corticosterone|
|R-SMAD binding|
|positive regulation of osteoclast differentiation|
|response to immobilization stress|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|response to mineralocorticoid|
|RNA polymerase II core promoter sequence-specific DNA binding|
|cellular response to cadmium ion|
|regulation of pri-miRNA transcription by RNA polymerase II|
|protein-DNA complex|
|response to progesterone|
|DNA methylation|
|DNA alkylation|
|response to cold|
|skeletal muscle cell differentiation|
|RNA polymerase II activating transcription factor binding|
|positive regulation of myeloid leukocyte differentiation|
|SMAD protein signal transduction|
|response to cadmium ion|
|regulation of osteoclast differentiation|
|DNA methylation or demethylation|
|associative learning|
|cellular response to calcium ion|
|feeding behavior|
|DNA modification|
|positive regulation of myeloid cell differentiation|
|positive regulation of neuron death|
|response to cAMP|
|transforming growth factor beta receptor signaling pathway|
|regulation of myeloid leukocyte differentiation|
|skeletal muscle tissue development|
|cellular response to reactive oxygen species|
|skeletal muscle organ development|
|response to organophosphorus|
|response to glucocorticoid|
|learning|
|positive regulation of leukocyte differentiation|
|response to calcium ion|
|response to purine-containing compound|
|cellular response to transforming growth factor beta stimulus|
|response to corticosteroid|
|response to transforming growth factor beta|
|Fc-epsilon receptor signaling pathway|
|response to temperature stimulus|
|female pregnancy|
|positive regulation of hemopoiesis|
|cellular response to metal ion|
|response to ketone|
|response to reactive oxygen species|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|multi-multicellular organism process|
|response to mechanical stimulus|
|transcription regulatory region DNA binding|
|cellular response to inorganic substance|
|regulation of myeloid cell differentiation|
|response to alcohol|
|cellular response to oxidative stress|
|Fc receptor signaling pathway|
|macromolecule methylation|
|learning or memory|
|cellular response to extracellular stimulus|
|regulation of leukocyte differentiation|
|aging|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|cognition|
|response to light stimulus|
|regulation of neuron death|
|methylation|
|response to lipopolysaccharide|
|neuron projection|
|response to molecule of bacterial origin|
|response to steroid hormone|
|cellular response to external stimulus|
|response to metal ion|
|response to oxidative stress|
|chromatin binding|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|muscle structure development|
|immune response-regulating cell surface receptor signaling pathway|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|inflammatory response|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|behavior|
|immune response-regulating signaling pathway|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|response to bacterium|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.82|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16114
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOS Expression in NALM6 Cells: -1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>