======= FOXA1 =======
== Gene Information ==
* **Official Symbol**: FOXA1
* **Official Name**: forkhead box A1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3169|3169]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P55317|P55317]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=FOXA1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXA1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/602294|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}.
|Fork head|
|Fork head N|
|HNF C|
|alveolar secondary septum development|
|respiratory basal cell differentiation|
|epithelial-mesenchymal signaling involved in prostate gland development|
|prostate gland stromal morphogenesis|
|epithelial cell maturation involved in prostate gland development|
|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|
|epithelial-mesenchymal cell signaling|
|lung saccule development|
|positive regulation of cell-cell adhesion mediated by cadherin|
|prostate glandular acinus development|
|epithelial cell differentiation involved in prostate gland development|
|positive regulation of intracellular estrogen receptor signaling pathway|
|positive regulation of intracellular steroid hormone receptor signaling pathway|
|epithelial cell maturation|
|dorsal/ventral neural tube patterning|
|regulation of cell-cell adhesion mediated by cadherin|
|lung epithelial cell differentiation|
|lung cell differentiation|
|prostate gland epithelium morphogenesis|
|prostate gland morphogenesis|
|epithelial tube branching involved in lung morphogenesis|
|negative regulation of epithelial to mesenchymal transition|
|dopaminergic neuron differentiation|
|lung epithelium development|
|positive regulation of smoothened signaling pathway|
|neuron fate specification|
|neural tube patterning|
|glandular epithelial cell differentiation|
|lung alveolus development|
|regulation of intracellular estrogen receptor signaling pathway|
|prostate gland development|
|lung morphogenesis|
|microvillus|
|neuron fate commitment|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of smoothened signaling pathway|
|dorsal/ventral pattern formation|
|regulation of epithelial to mesenchymal transition|
|cell fate specification|
|columnar/cuboidal epithelial cell differentiation|
|gland morphogenesis|
|Notch signaling pathway|
|branching morphogenesis of an epithelial tube|
|fibrillar center|
|anatomical structure maturation|
|response to estradiol|
|positive regulation of mitotic cell cycle|
|cell maturation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|neural tube development|
|chromatin remodeling|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|glucose homeostasis|
|carbohydrate homeostasis|
|epithelial cell development|
|respiratory system development|
|hormone metabolic process|
|transcription regulatory region DNA binding|
|connective tissue development|
|developmental maturation|
|protein domain specific binding|
|cell fate commitment|
|positive regulation of cell-cell adhesion|
|positive regulation of DNA-binding transcription factor activity|
|epithelial tube morphogenesis|
|urogenital system development|
|transcription factor binding|
|regionalization|
|positive regulation of neuron differentiation|
|positive regulation of cell cycle|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|gland development|
|sequence-specific DNA binding|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|tissue morphogenesis|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|epithelial cell differentiation|
|positive regulation of cell death|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|neuron differentiation|
|chromosome organization|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.95|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|9/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 7244
* **Expression level (log2 read counts)**: -2.43
{{:chemogenomics:nalm6 dist.png?nolink |}}