======= FOXD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXD1
  * **<color #00a2e8>Official Name</color>**: forkhead box D1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2297|2297]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16676|Q16676]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601091|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902). {ECO:0000250|UniProtKB:Q61345, ECO:0000269|PubMed:27805902}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metanephric capsule development|
|renal capsule morphogenesis|
|metanephric capsule morphogenesis|
|metanephric capsule specification|
|renal capsule development|
|metanephric capsule formation|
|renal capsule specification|
|renal capsule formation|
|dichotomous subdivision of terminal units involved in ureteric bud branching|
|nephrogenic mesenchyme development|
|luteinizing hormone secretion|
|gonadotropin secretion|
|pattern specification involved in metanephros development|
|renal system pattern specification|
|pattern specification involved in kidney development|
|dichotomous subdivision of an epithelial terminal unit|
|endocrine hormone secretion|
|kidney mesenchyme development|
|DNA binding, bending|
|metanephric nephron development|
|positive regulation of BMP signaling pathway|
|positive regulation of kidney development|
|branching involved in ureteric bud morphogenesis|
|endocrine process|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|hormone secretion|
|nephron tubule development|
|renal tubule development|
|hormone transport|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|regulation of BMP signaling pathway|
|mesonephros development|
|nephron epithelium development|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nephron development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|signal release|
|mesenchyme development|
|connective tissue development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|axon guidance|
|neuron projection guidance|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|regionalization|
|axonogenesis|
|axon development|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|regulation of hormone levels|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|tube morphogenesis|
|neuron projection development|
|DNA-binding transcription factor activity|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|secretion by cell|
|neuron differentiation|
|export from cell|
|epithelium development|
|cell-cell signaling|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.24|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.91|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXD1 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>