======= FOXN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXN4
  * **<color #00a2e8>Official Name</color>**: forkhead box N4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=121643|121643]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96NZ1|Q96NZ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609429|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|amacrine cell differentiation|
|atrioventricular canal development|
|ventral spinal cord interneuron fate commitment|
|cell fate commitment involved in pattern specification|
|ventral spinal cord interneuron differentiation|
|retina layer formation|
|spinal cord dorsal/ventral patterning|
|spinal cord patterning|
|enhancer sequence-specific DNA binding|
|ventral spinal cord development|
|retina morphogenesis in camera-type eye|
|cell differentiation in spinal cord|
|neural retina development|
|heart looping|
|neuron fate commitment|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube development|
|dorsal/ventral pattern formation|
|spinal cord development|
|camera-type eye morphogenesis|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|retina development in camera-type eye|
|eye morphogenesis|
|central nervous system neuron differentiation|
|regulation of heart contraction|
|cell fate commitment|
|heart morphogenesis|
|sensory organ morphogenesis|
|regulation of blood circulation|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|camera-type eye development|
|regionalization|
|eye development|
|visual system development|
|sensory system development|
|chromatin binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|heart development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of system process|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6782
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXN4 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>