======= FOXO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXO1
  * **<color #00a2e8>Official Name</color>**: forkhead box O1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2308|2308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12778|Q12778]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain.  The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide- damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). {ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to fluoride|
|negative regulation of cardiac muscle hypertrophy in response to stress|
|negative regulation of cardiac muscle adaptation|
|cellular response to hyperoxia|
|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|
|cellular response to cold|
|regulation of cardiac muscle adaptation|
|regulation of cardiac muscle hypertrophy in response to stress|
|negative regulation of muscle adaptation|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|enamel mineralization|
|positive regulation of gluconeogenesis|
|cellular response to increased oxygen levels|
|tooth mineralization|
|cellular response to nitric oxide|
|response to nitric oxide|
|cellular response to reactive nitrogen species|
|transcription coactivator binding|
|response to hyperoxia|
|amelogenesis|
|neuronal stem cell population maintenance|
|negative regulation of cardiac muscle hypertrophy|
|negative regulation of muscle hypertrophy|
|response to increased oxygen levels|
|temperature homeostasis|
|cellular response to dexamethasone stimulus|
|protein phosphatase 2A binding|
|energy homeostasis|
|endocrine pancreas development|
|positive regulation of glucose metabolic process|
|response to dexamethasone|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|regulation of gluconeogenesis|
|negative regulation of fat cell differentiation|
|response to cold|
|response to bronchodilator|
|regulation of cardiac muscle hypertrophy|
|cellular response to glucocorticoid stimulus|
|positive regulation of cellular carbohydrate metabolic process|
|cellular response to corticosteroid stimulus|
|regulation of muscle hypertrophy|
|cellular response to hydrogen peroxide|
|pancreas development|
|positive regulation of carbohydrate metabolic process|
|odontogenesis of dentin-containing tooth|
|beta-catenin binding|
|regulation of muscle adaptation|
|insulin receptor signaling pathway|
|cellular glucose homeostasis|
|regulation of neural precursor cell proliferation|
|cellular response to ketone|
|biomineral tissue development|
|biomineralization|
|regulation of carbohydrate biosynthetic process|
|response to antineoplastic agent|
|fat cell differentiation|
|regulation of glucose metabolic process|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|positive regulation of autophagy|
|odontogenesis|
|endocrine system development|
|regulation of fat cell differentiation|
|cellular response to reactive oxygen species|
|stem cell population maintenance|
|maintenance of cell number|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|protein acetylation|
|response to glucocorticoid|
|cellular response to starvation|
|response to corticosteroid|
|cellular response to insulin stimulus|
|negative regulation of MAPK cascade|
|negative regulation of canonical Wnt signaling pathway|
|response to temperature stimulus|
|regulation of reactive oxygen species metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to xenobiotic stimulus|
|protein acylation|
|cellular response to steroid hormone stimulus|
|response to ketone|
|response to starvation|
|response to reactive oxygen species|
|regulation of carbohydrate metabolic process|
|negative regulation of Wnt signaling pathway|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|positive regulation of protein catabolic process|
|cellular response to inorganic substance|
|response to insulin|
|cellular response to nutrient levels|
|regulation of stress-activated MAPK cascade|
|regulation of muscle system process|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|autophagy|
|process utilizing autophagic mechanism|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|regulation of canonical Wnt signaling pathway|
|ubiquitin protein ligase binding|
|response to xenobiotic stimulus|
|response to antibiotic|
|multicellular organismal homeostasis|
|cellular response to peptide|
|response to steroid hormone|
|regulation of autophagy|
|transcription factor binding|
|cellular response to external stimulus|
|response to acid chemical|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|response to oxygen levels|
|regulation of protein catabolic process|
|response to oxidative stress|
|response to peptide hormone|
|chromatin binding|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|response to peptide|
|blood vessel development|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|cellular response to lipid|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.3|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.88|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.7|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.73|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.96|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.08|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.15|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.39|
|[[:results:exp504|MK2206 4μM R08 exp504]]|7.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.587|
|[[:human genes:p:pten|PTEN]]|0.527|
|[[:human genes:c:csk|CSK]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4127
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXO1 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>