======= FOXP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXP2
  * **<color #00a2e8>Official Name</color>**: forkhead box P2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93986|93986]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15409|O15409]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605317|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|innate vocalization behavior|
|caudate nucleus development|
|putamen development|
|positive regulation of epithelial cell proliferation involved in lung morphogenesis|
|regulation of epithelial cell proliferation involved in lung morphogenesis|
|righting reflex|
|vocal learning|
|imitative learning|
|observational learning|
|learned vocalization behavior or vocal learning|
|auditory behavior|
|mechanosensory behavior|
|smooth muscle tissue development|
|vocalization behavior|
|striatum development|
|reflex|
|subpallium development|
|positive regulation of mesenchymal cell proliferation|
|response to auditory stimulus|
|regulation of mesenchymal cell proliferation|
|response to testosterone|
|lung alveolus development|
|androgen receptor binding|
|neural nucleus development|
|positive regulation of animal organ morphogenesis|
|post-embryonic development|
|cerebellum development|
|metencephalon development|
|cerebral cortex development|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|learning|
|hindbrain development|
|lung development|
|respiratory tube development|
|pallium development|
|positive regulation of epithelial cell proliferation|
|response to ketone|
|respiratory system development|
|response to mechanical stimulus|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|telencephalon development|
|regulation of animal organ morphogenesis|
|learning or memory|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|cognition|
|camera-type eye development|
|regulation of epithelial cell proliferation|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|sequence-specific DNA binding|
|muscle structure development|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|behavior|
|DNA-binding transcription factor activity|
|brain development|
|head development|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|central nervous system development|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13718
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXP2 Expression in NALM6 Cells: 2.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>