======= FOXRED1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXRED1
  * **<color #00a2e8>Official Name</color>**: FAD dependent oxidoreductase domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55572|55572]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CU9|Q96CU9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXRED1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXRED1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613622|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial respiratory chain complex assembly|
|oxidoreductase activity|
|mitochondrial inner membrane|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.7|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.73|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.73|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.74|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.85|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.89|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.91|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.95|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.98|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.04|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.09|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.11|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.13|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.21|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.28|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.34|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|4.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.578|
|[[:human genes:g:grsf1|GRSF1]]|0.565|
|[[:human genes:n:ndufa2|NDUFA2]]|0.557|
|[[:human genes:n:ndufb11|NDUFB11]]|0.551|
|[[:human genes:n:nubpl|NUBPL]]|0.536|
|[[:human genes:n:ndufa1|NDUFA1]]|0.536|
|[[:human genes:m:mto1|MTO1]]|0.53|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.529|
|[[:human genes:n:ndufb5|NDUFB5]]|0.527|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.519|
|[[:human genes:n:ndufa11|NDUFA11]]|0.518|
|[[:human genes:g:gfm2|GFM2]]|0.517|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.516|
|[[:human genes:c:coq7|COQ7]]|0.514|
|[[:human genes:f:fastkd2|FASTKD2]]|0.512|
|[[:human genes:n:ndufs7|NDUFS7]]|0.51|
|[[:human genes:n:ndufa3|NDUFA3]]|0.507|
|[[:human genes:n:ndufs2|NDUFS2]]|0.505|
|[[:human genes:n:ndufb9|NDUFB9]]|0.502|
|[[:human genes:a:acad9|ACAD9]]|0.501|
|[[:human genes:e:ecsit|ECSIT]]|0.5|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.496|
|[[:human genes:n:ndufb7|NDUFB7]]|0.495|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.495|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.487|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.483|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.482|
|[[:human genes:n:ndufb6|NDUFB6]]|0.475|
|[[:human genes:n:ndufs5|NDUFS5]]|0.474|
|[[:human genes:i:iba57|IBA57]]|0.474|
|[[:human genes:c:c12orf65|C12orf65]]|0.474|
|[[:human genes:n:ndufb10|NDUFB10]]|0.473|
|[[:human genes:n:ndufs8|NDUFS8]]|0.469|
|[[:human genes:s:sfxn4|SFXN4]]|0.469|
|[[:human genes:t:tmem261|TMEM261]]|0.468|
|[[:human genes:m:mrps5|MRPS5]]|0.463|
|[[:human genes:m:mtif2|MTIF2]]|0.462|
|[[:human genes:m:mrpl45|MRPL45]]|0.461|
|[[:human genes:r:rpusd3|RPUSD3]]|0.461|
|[[:human genes:m:mrpl15|MRPL15]]|0.459|
|[[:human genes:n:ndufc2|NDUFC2]]|0.454|
|[[:human genes:a:atp5sl|ATP5SL]]|0.451|
|[[:human genes:n:ndufa8|NDUFA8]]|0.448|
|[[:human genes:m:mrpl12|MRPL12]]|0.446|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.444|
|[[:human genes:f:ftsj2|FTSJ2]]|0.442|
|[[:human genes:n:ndufa10|NDUFA10]]|0.441|
|[[:human genes:c:c17orf89|C17orf89]]|0.441|
|[[:human genes:t:tmem126b|TMEM126B]]|0.44|
|[[:human genes:p:polg2|POLG2]]|0.44|
|[[:human genes:y:yars2|YARS2]]|0.439|
|[[:human genes:m:mcat|MCAT]]|0.437|
|[[:human genes:n:ndufs1|NDUFS1]]|0.436|
|[[:human genes:m:mettl17|METTL17]]|0.431|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.431|
|[[:human genes:g:gfm1|GFM1]]|0.431|
|[[:human genes:q:qrsl1|QRSL1]]|0.43|
|[[:human genes:n:ndufa6|NDUFA6]]|0.43|
|[[:human genes:n:ndufb2|NDUFB2]]|0.43|
|[[:human genes:c:chchd1|CHCHD1]]|0.426|
|[[:human genes:p:pet112|PET112]]|0.423|
|[[:human genes:m:mipep|MIPEP]]|0.421|
|[[:human genes:p:polg|POLG]]|0.421|
|[[:human genes:c:coa6|COA6]]|0.42|
|[[:human genes:n:noa1|NOA1]]|0.417|
|[[:human genes:c:cars2|CARS2]]|0.417|
|[[:human genes:m:mrp63|MRP63]]|0.415|
|[[:human genes:m:mrpl44|MRPL44]]|0.412|
|[[:human genes:l:lars2|LARS2]]|0.411|
|[[:human genes:w:wars2|WARS2]]|0.41|
|[[:human genes:n:ndufv2|NDUFV2]]|0.407|
|[[:human genes:n:nfu1|NFU1]]|0.407|
|[[:human genes:n:ndufa5|NDUFA5]]|0.405|
|[[:human genes:m:mtg1|MTG1]]|0.4|
|[[:human genes:n:ndufa9|NDUFA9]]|0.4|
|[[:human genes:c:coq2|COQ2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1738
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXRED1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>