======= FRMD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FRMD7
  * **<color #00a2e8>Official Name</color>**: FERM domain containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90167|90167]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZUT3|Q6ZUT3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FRMD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FRMD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300628|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mutations in this gene are associated with X-linked congenital nystagmus. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. {ECO:0000250|UniProtKB:A2AD83, ECO:0000269|PubMed:17013395, ECO:0000269|PubMed:23946638}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FA|
|FERM C|
|FERM M|
|FERM N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rac guanyl-nucleotide exchange factor activity|
|positive regulation of lamellipodium assembly|
|negative regulation of stress fiber assembly|
|negative regulation of actin filament bundle assembly|
|positive regulation of lamellipodium organization|
|regulation of lamellipodium assembly|
|regulation of lamellipodium organization|
|positive regulation of small GTPase mediated signal transduction|
|regulation of stress fiber assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|positive regulation of plasma membrane bounded cell projection assembly|
|negative regulation of protein binding|
|growth cone|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|negative regulation of binding|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of protein binding|
|regulation of actin filament organization|
|neuron projection|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|neuronal cell body|
|negative regulation of organelle organization|
|regulation of binding|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|regulation of neuron projection development|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|molecular function|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of intracellular signal transduction|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|generation of neurons|
|extracellular space|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18158
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FRMD7 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>