======= FRY =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FRY
  * **<color #00a2e8>Official Name</color>**: FRY microtubule binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10129|10129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TBA9|Q5TBA9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FRY&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FRY|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614818|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of tubulin deacetylation|
|regulation of tubulin deacetylation|
|enzyme inhibitor activity|
|regulation of protein deacetylation|
|spindle pole|
|cell cortex|
|microtubule organizing center|
|negative regulation of protein modification process|
|neuron projection development|
|cell morphogenesis|
|negative regulation of catalytic activity|
|neuron development|
|cellular component morphogenesis|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|generation of neurons|
|neurogenesis|
|cell development|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.12|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.07|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.03|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.92|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.87|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.87|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.76|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.76|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.71|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16290
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FRY Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>