======= FST =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FST
  * **<color #00a2e8>Official Name</color>**: follistatin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10468|10468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19883|P19883]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FST&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FST|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release.  The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA.  In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kazal 2|
|FOLN|
|Kazal 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activin receptor antagonist activity|
|negative regulation of activin receptor signaling pathway|
|positive regulation of hair follicle development|
|positive regulation of hair cycle|
|activin binding|
|heparan sulfate proteoglycan binding|
|regulation of hair follicle development|
|regulation of activin receptor signaling pathway|
|regulation of hair cycle|
|positive regulation of epidermis development|
|regulation of epidermis development|
|hematopoietic progenitor cell differentiation|
|regulation of BMP signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|extracellular space|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FST Expression in NALM6 Cells: -0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>