======= FTCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FTCD
  * **<color #00a2e8>Official Name</color>**: formimidoyltransferase cyclodeaminase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10841|10841]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95954|O95954]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FTCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FTCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606806|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FTCD N|
|FTCD C|
|FTCD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate formimidoyltransferase activity|
|formimidoyltetrahydrofolate cyclodeaminase activity|
|formimidoyltransferase activity|
|formamide metabolic process|
|histidine catabolic process to glutamate and formate|
|histidine catabolic process to glutamate and formamide|
|formate metabolic process|
|smooth endoplasmic reticulum membrane|
|imidazole-containing compound catabolic process|
|histidine catabolic process|
|histidine metabolic process|
|tetrahydrofolate interconversion|
|folic acid binding|
|imidazole-containing compound metabolic process|
|tetrahydrofolate metabolic process|
|one-carbon metabolic process|
|aromatic amino acid family catabolic process|
|folic acid-containing compound metabolic process|
|glutamate metabolic process|
|pteridine-containing compound metabolic process|
|aromatic amino acid family metabolic process|
|glutamine family amino acid metabolic process|
|endoplasmic reticulum-Golgi intermediate compartment|
|dicarboxylic acid metabolic process|
|antibiotic metabolic process|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|centriole|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|microtubule binding|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|cellular amino acid metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|Golgi membrane|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|Golgi apparatus|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|cytoskeleton organization|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5154
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FTCD Expression in NALM6 Cells: -2.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>