======= FZD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZD1
  * **<color #00a2e8>Official Name</color>**: frizzled class receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8321|8321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UP38|Q9UP38]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603408|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:O70421, ECO:0000269|PubMed:10557084, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Frizzled|
|Fz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mesenchymal stem cell differentiation|
|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|
|canonical Wnt signaling pathway involved in osteoblast differentiation|
|muscular septum morphogenesis|
|hard palate development|
|autocrine signaling|
|membranous septum morphogenesis|
|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|midbrain dopaminergic neuron differentiation|
|Wnt signalosome|
|planar cell polarity pathway involved in neural tube closure|
|regulation of establishment of planar polarity involved in neural tube closure|
|Wnt-activated receptor activity|
|presynapse assembly|
|regulation of epithelial tube formation|
|negative regulation of oxidative stress-induced neuron death|
|beta-catenin destruction complex disassembly|
|presynapse organization|
|secondary palate development|
|regulation of oxidative stress-induced neuron death|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|dopaminergic neuron differentiation|
|Wnt-protein binding|
|frizzled binding|
|ventricular septum morphogenesis|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of response to oxidative stress|
|negative regulation of BMP signaling pathway|
|regulation of oxidative stress-induced cell death|
|ventricular septum development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|regulation of cellular response to oxidative stress|
|muscle tissue morphogenesis|
|regulation of response to oxidative stress|
|midbrain development|
|muscle organ morphogenesis|
|PDZ domain binding|
|regulation of BMP signaling pathway|
|roof of mouth development|
|canonical Wnt signaling pathway|
|neural tube closure|
|tube closure|
|synapse assembly|
|Wnt signaling pathway, planar cell polarity pathway|
|primary neural tube formation|
|regulation of synapse assembly|
|neural tube formation|
|cardiac septum development|
|regulation of establishment of planar polarity|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|embryonic epithelial tube formation|
|osteoblast differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of embryonic development|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|morphogenesis of embryonic epithelium|
|negative regulation of cellular response to growth factor stimulus|
|tube formation|
|stem cell differentiation|
|neural tube development|
|cardiac chamber development|
|negative regulation of canonical Wnt signaling pathway|
|central nervous system neuron differentiation|
|regulation of morphogenesis of an epithelium|
|negative regulation of neuron death|
|negative regulation of Wnt signaling pathway|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein-containing complex disassembly|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|ossification|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|muscle organ development|
|epithelial tube morphogenesis|
|regulation of neuron death|
|signaling receptor binding|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|cellular component disassembly|
|focal adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|positive regulation of neurogenesis|
|muscle structure development|
|regulation of neuron projection development|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|tissue morphogenesis|
|embryonic morphogenesis|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|brain development|
|head development|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.467|
|[[:human genes:p:prim1|PRIM1]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17595
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZD1 Expression in NALM6 Cells: 3.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>