======= GABARAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GABARAP
  * **<color #00a2e8>Official Name</color>**: GABA type A receptor-associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11337|11337]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95166|O95166]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GABARAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GABARAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269|PubMed:15977068}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Atg8|
|APG12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to nitrogen levels|
|cellular response to nitrogen starvation|
|GABA receptor binding|
|sperm midpiece|
|smooth endoplasmic reticulum|
|microtubule associated complex|
|autophagosome maturation|
|autophagosome membrane|
|extrinsic apoptotic signaling pathway via death domain receptors|
|beta-tubulin binding|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|autophagosome assembly|
|organelle disassembly|
|autophagosome organization|
|autophagosome|
|cell body|
|extrinsic apoptotic signaling pathway|
|axoneme|
|vacuole organization|
|cellular response to starvation|
|macroautophagy|
|response to starvation|
|actin cytoskeleton|
|cellular response to nutrient levels|
|microtubule binding|
|protein-containing complex disassembly|
|lysosome|
|cytoplasmic vesicle|
|autophagy|
|process utilizing autophagic mechanism|
|cellular response to extracellular stimulus|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|microtubule|
|cellular response to external stimulus|
|protein targeting|
|cellular component disassembly|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|mitochondrion organization|
|synaptic signaling|
|microtubule cytoskeleton organization|
|response to nutrient levels|
|response to extracellular stimulus|
|Golgi membrane|
|microtubule-based process|
|perinuclear region of cytoplasm|
|organelle assembly|
|apoptotic process|
|intracellular protein transport|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|cell-cell signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.2|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.9|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.97|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.05|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fnip1|FNIP1]]|0.468|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7710
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GABARAP Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>