======= GABPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GABPA
  * **<color #00a2e8>Official Name</color>**: GA binding protein transcription factor subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2551|2551]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06546|Q06546]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GABPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GABPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600609|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GABP-alpha|
|Ets|
|SAM PNT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of megakaryocyte differentiation|
|activating transcription factor binding|
|blastocyst formation|
|regulation of megakaryocyte differentiation|
|negative regulation of myeloid cell differentiation|
|cellular response to dopamine|
|response to dopamine|
|blastocyst development|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to catecholamine|
|response to monoamine|
|cellular response to ammonium ion|
|negative regulation of hemopoiesis|
|response to ammonium ion|
|transcription regulatory region DNA binding|
|regulation of myeloid cell differentiation|
|nuclear chromatin|
|transcription coactivator activity|
|in utero embryonic development|
|chromatin binding|
|cellular response to drug|
|mitochondrion organization|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|response to organic cyclic compound|
|negative regulation of developmental process|
|embryo development|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.05|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.25|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.48|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.659|
|[[:human genes:d:diablo|DIABLO]]|0.539|
|[[:human genes:a:apaf1|APAF1]]|0.536|
|[[:human genes:p:plaa|PLAA]]|0.529|
|[[:human genes:m:mfn1|MFN1]]|0.521|
|[[:human genes:f:faf2|FAF2]]|0.516|
|[[:human genes:c:casp9|CASP9]]|0.516|
|[[:human genes:c:cycs|CYCS]]|0.515|
|[[:human genes:m:meaf6|MEAF6]]|0.51|
|[[:human genes:h:hspd1|HSPD1]]|0.51|
|[[:human genes:b:bak1|BAK1]]|0.509|
|[[:human genes:e:eny2|ENY2]]|0.503|
|[[:human genes:s:serf2|SERF2]]|0.502|
|[[:human genes:u:ubqln1|UBQLN1]]|0.499|
|[[:human genes:v:vdac2|VDAC2]]|0.494|
|[[:human genes:m:march5|MARCH5]]|0.485|
|[[:human genes:n:nxt1|NXT1]]|0.471|
|[[:human genes:d:dohh|DOHH]]|0.467|
|[[:human genes:s:stau1|STAU1]]|0.462|
|[[:human genes:h:hccs|HCCS]]|0.457|
|[[:human genes:u:ube2k|UBE2K]]|0.455|
|[[:human genes:a:atad1|ATAD1]]|0.446|
|[[:human genes:g:gfpt1|GFPT1]]|0.435|
|[[:human genes:b:bap1|BAP1]]|0.434|
|[[:human genes:t:triap1|TRIAP1]]|0.431|
|[[:human genes:f:fbxo11|FBXO11]]|0.43|
|[[:human genes:a:atp5j|ATP5J]]|0.422|
|[[:human genes:r:rptor|RPTOR]]|0.412|
|[[:human genes:r:rnmt|RNMT]]|0.407|
|[[:human genes:p:pelo|PELO]]|0.402|
|[[:human genes:r:rad23b|RAD23B]]|0.402|
|[[:human genes:d:dhps|DHPS]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GABPA Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>