======= GABRA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GABRA4
  * **<color #00a2e8>Official Name</color>**: gamma-aminobutyric acid type A receptor subunit alpha4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2557|2557]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48169|P48169]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GABRA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GABRA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan LBD|
|Neur chan memb|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|benzodiazepine receptor activity|
|inhibitory extracellular ligand-gated ion channel activity|
|GABA-gated chloride ion channel activity|
|synaptic transmission, GABAergic|
|GABA-A receptor activity|
|GABA-A receptor complex|
|gamma-aminobutyric acid signaling pathway|
|integral component of postsynaptic specialization membrane|
|dendrite membrane|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|chloride channel complex|
|extracellular ligand-gated ion channel activity|
|chloride channel activity|
|GABA-ergic synapse|
|postsynapse|
|chloride transmembrane transport|
|regulation of response to drug|
|regulation of postsynaptic membrane potential|
|chloride transport|
|inorganic anion transmembrane transport|
|inorganic anion transport|
|synapse|
|anion transmembrane transport|
|neuron projection|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|cell junction|
|anion transport|
|inorganic ion transmembrane transport|
|ion transmembrane transport|
|central nervous system development|
|cell-cell signaling|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16740
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GABRA4 Expression in NALM6 Cells: 0.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>