======= GAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAD1
  * **<color #00a2e8>Official Name</color>**: glutamate decarboxylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2571|2571]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99259|Q99259]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605363|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the production of GABA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyridoxal deC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate decarboxylase activity|
|protein-pyridoxal-5-phosphate linkage|
|glutamate decarboxylation to succinate|
|gamma-aminobutyric acid biosynthetic process|
|gamma-aminobutyric acid metabolic process|
|glutamate catabolic process|
|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|
|glutamate binding|
|protein-cofactor linkage|
|locomotory exploration behavior|
|inhibitory synapse|
|dicarboxylic acid catabolic process|
|glutamine family amino acid catabolic process|
|exploration behavior|
|vesicle membrane|
|glutamate metabolic process|
|presynaptic active zone|
|neurotransmitter biosynthetic process|
|axon terminus|
|intraspecies interaction between organisms|
|social behavior|
|pyridoxal phosphate binding|
|multi-organism behavior|
|glutamine family amino acid metabolic process|
|cellular amino acid biosynthetic process|
|neurotransmitter metabolic process|
|dicarboxylic acid metabolic process|
|neurotransmitter secretion|
|signal release from synapse|
|alpha-amino acid catabolic process|
|protein N-terminus binding|
|cellular amino acid catabolic process|
|cell cortex|
|signal release|
|neurotransmitter transport|
|monocarboxylic acid biosynthetic process|
|locomotory behavior|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|regulation of neurotransmitter levels|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|small molecule catabolic process|
|synaptic signaling|
|protein heterodimerization activity|
|monocarboxylic acid metabolic process|
|behavior|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|secretion by cell|
|response to drug|
|organic acid metabolic process|
|export from cell|
|organonitrogen compound catabolic process|
|cell-cell signaling|
|secretion|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.79|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16123
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAD1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>