======= GAL3ST1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAL3ST1
  * **<color #00a2e8>Official Name</color>**: galactose-3-O-sulfotransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9514|9514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99999|Q99999]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAL3ST1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAL3ST1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602300|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000250, ECO:0000269|PubMed:8830034}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gal-3-0 sulfotr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|galactosylceramide sulfotransferase activity|
|galactosylceramide biosynthetic process|
|galactolipid biosynthetic process|
|glycosylceramide biosynthetic process|
|galactosylceramide metabolic process|
|galactolipid metabolic process|
|glycosylceramide metabolic process|
|glycosphingolipid biosynthetic process|
|sulfotransferase activity|
|ceramide biosynthetic process|
|glycolipid biosynthetic process|
|glycosphingolipid metabolic process|
|protein N-linked glycosylation|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|myelination|
|ensheathment of neurons|
|axon ensheathment|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|membrane lipid metabolic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|amide biosynthetic process|
|spermatogenesis|
|male gamete generation|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|gamete generation|
|cellular amide metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3523
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAL3ST1 Expression in NALM6 Cells: -1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>