======= GAP43 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAP43
  * **<color #00a2e8>Official Name</color>**: growth associated protein 43
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2596|2596]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17677|P17677]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAP43&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAP43|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neuromodulin|
|Neuromodulin N|
|IQ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysophosphatidic acid binding|
|axon choice point recognition|
|growth cone membrane|
|regulation of postsynaptic specialization assembly|
|regulation of postsynapse assembly|
|phosphatidylinositol phosphate binding|
|filopodium membrane|
|axon regeneration|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|neuron projection regeneration|
|regulation of filopodium assembly|
|neuron recognition|
|response to axon injury|
|phosphatidylserine binding|
|tissue regeneration|
|GABA-ergic synapse|
|regulation of postsynapse organization|
|regulation of synapse assembly|
|regeneration|
|glial cell differentiation|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|calmodulin binding|
|gliogenesis|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|cell recognition|
|cell fate commitment|
|postsynaptic density|
|axon guidance|
|neuron projection guidance|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|cell junction|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|response to wounding|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cellular component biogenesis|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|cellular response to stress|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.71|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.04|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11301
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAP43 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>