======= GAPDHS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAPDHS
  * **<color #00a2e8>Official Name</color>**: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26330|26330]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14556|O14556]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAPDHS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAPDHS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609169|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gp dh N|
|Gp dh C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|
|positive regulation of glycolytic process|
|canonical glycolysis|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|NADP binding|
|NAD binding|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|NAD metabolic process|
|hexose biosynthetic process|
|ADP metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|nucleoside diphosphate phosphorylation|
|monosaccharide catabolic process|
|purine nucleoside diphosphate metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|flagellated sperm motility|
|sperm motility|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|nucleoside diphosphate metabolic process|
|regulation of carbohydrate catabolic process|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|carbohydrate catabolic process|
|regulation of ATP metabolic process|
|carbohydrate biosynthetic process|
|positive regulation of small molecule metabolic process|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|ATP metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|positive regulation of cellular catabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|phosphorylation|
|locomotion|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.86|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.88|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.91|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.06|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.11|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAPDHS Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>