======= GART =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GART
  * **<color #00a2e8>Official Name</color>**: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2618|2618]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22102|P22102]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GART&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GART|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AIRS C|
|GARS C|
|GARS N|
|Formyl trans N|
|AIRS|
|GARS A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoribosylglycinamide formyltransferase activity|
|phosphoribosylamine-glycine ligase activity|
|phosphoribosylformylglycinamidine cyclo-ligase activity|
|adenine biosynthetic process|
|adenine metabolic process|
|de novo IMP biosynthetic process|
|tetrahydrofolate biosynthetic process|
|brainstem development|
|IMP biosynthetic process|
|folic acid-containing compound biosynthetic process|
|purine nucleobase biosynthetic process|
|IMP metabolic process|
|pteridine-containing compound biosynthetic process|
|glycine metabolic process|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate biosynthetic process|
|tetrahydrofolate metabolic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|folic acid-containing compound metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|pteridine-containing compound metabolic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|serine family amino acid metabolic process|
|nucleobase metabolic process|
|nucleoside monophosphate biosynthetic process|
|cellular modified amino acid biosynthetic process|
|pigment biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|pigment metabolic process|
|nucleoside monophosphate metabolic process|
|neurotransmitter metabolic process|
|cerebellum development|
|metencephalon development|
|cerebral cortex development|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|hindbrain development|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|pallium development|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|telencephalon development|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|regulation of neurotransmitter levels|
|purine-containing compound metabolic process|
|forebrain development|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|amide biosynthetic process|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|brain development|
|head development|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.89|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.75|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.76|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.76|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.89|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.94|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.05|
|[[:results:exp100|NFN1 1μM R03 exp100]]|2.06|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.08|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mthfd1|MTHFD1]]|0.494|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 106
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GART Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>