======= GATA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATA5
  * **<color #00a2e8>Official Name</color>**: GATA binding protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140628|140628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BWX5|Q9BWX5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GATA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611496|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888). {ECO:0000250|UniProtKB:P97489, ECO:0000269|PubMed:23289003, ECO:0000269|PubMed:25543888}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GATA|
|GATA-N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cardiac endothelial to mesenchymal transition|
|positive regulation of cardiac endothelial to mesenchymal transition|
|regulation of Notch signaling pathway involved in heart induction|
|endocardial cushion fusion|
|positive regulation of Notch signaling pathway involved in heart induction|
|positive regulation of transcription from RNA polymerase II promoter involved in heart development|
|positive regulation of heart induction|
|cell adhesion involved in heart morphogenesis|
|regulation of heart induction|
|regulation of transcription from RNA polymerase II promoter involved in heart development|
|intestinal epithelial cell differentiation|
|enhancer sequence-specific DNA binding|
|negative regulation of cardiac muscle hypertrophy|
|aortic valve morphogenesis|
|negative regulation of muscle hypertrophy|
|aortic valve development|
|endocardial cushion morphogenesis|
|regulation of animal organ formation|
|semi-lunar valve development|
|regulation of heart morphogenesis|
|endocardial cushion development|
|mesenchyme morphogenesis|
|positive regulation of Notch signaling pathway|
|heart valve morphogenesis|
|regulation of cardiac muscle hypertrophy|
|regulation of muscle hypertrophy|
|heart valve development|
|positive regulation of animal organ morphogenesis|
|regulation of muscle adaptation|
|columnar/cuboidal epithelial cell differentiation|
|regulation of Notch signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|digestive tract development|
|digestive system development|
|cardiac muscle tissue development|
|transcription regulatory region DNA binding|
|mesenchyme development|
|regulation of muscle system process|
|nuclear chromatin|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|striated muscle tissue development|
|blood coagulation|
|coagulation|
|muscle tissue development|
|hemostasis|
|wound healing|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell-cell adhesion|
|heart development|
|response to growth factor|
|tissue morphogenesis|
|response to wounding|
|regulation of system process|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|zinc ion binding|
|tube development|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7074
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GATA5 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>