======= GATC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATC
  * **<color #00a2e8>Official Name</color>**: glutamyl-tRNA amidotransferase subunit C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283459|283459]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43716|O43716]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GATC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03149, ECO:0000269|PubMed:19805282}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glu-tRNAGln|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutaminyl-tRNAGln biosynthesis via transamidation|
|glutamyl-tRNA(Gln) amidotransferase complex|
|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|
|regulation of translational fidelity|
|tRNA aminoacylation|
|amino acid activation|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.92|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.71|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.7|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.78|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.78|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.79|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.88|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.91|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.93|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.03|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.04|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.1|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.15|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.18|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.23|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.27|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.38|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.54|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yars2|YARS2]]|0.663|
|[[:human genes:m:mrps5|MRPS5]]|0.657|
|[[:human genes:t:tars2|TARS2]]|0.636|
|[[:human genes:n:nars2|NARS2]]|0.635|
|[[:human genes:p:pars2|PARS2]]|0.63|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.627|
|[[:human genes:s:selrc1|SELRC1]]|0.621|
|[[:human genes:e:ears2|EARS2]]|0.616|
|[[:human genes:f:fastkd5|FASTKD5]]|0.615|
|[[:human genes:m:mrpl21|MRPL21]]|0.613|
|[[:human genes:m:mrps16|MRPS16]]|0.613|
|[[:human genes:d:dap3|DAP3]]|0.612|
|[[:human genes:m:mrps21|MRPS21]]|0.609|
|[[:human genes:q:qrsl1|QRSL1]]|0.607|
|[[:human genes:t:tefm|TEFM]]|0.603|
|[[:human genes:m:mrpl53|MRPL53]]|0.602|
|[[:human genes:r:rpusd4|RPUSD4]]|0.599|
|[[:human genes:m:mrpl23|MRPL23]]|0.597|
|[[:human genes:m:mrps6|MRPS6]]|0.596|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.589|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.588|
|[[:human genes:m:mrps34|MRPS34]]|0.587|
|[[:human genes:r:rbfa|RBFA]]|0.586|
|[[:human genes:a:atp5d|ATP5D]]|0.581|
|[[:human genes:c:cox16|COX16]]|0.58|
|[[:human genes:n:ndufb11|NDUFB11]]|0.578|
|[[:human genes:s:sco2|SCO2]]|0.578|
|[[:human genes:p:polg|POLG]]|0.569|
|[[:human genes:l:lars2|LARS2]]|0.568|
|[[:human genes:v:vars2|VARS2]]|0.567|
|[[:human genes:r:rars2|RARS2]]|0.563|
|[[:human genes:m:mars2|MARS2]]|0.562|
|[[:human genes:m:mrps17|MRPS17]]|0.561|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.561|
|[[:human genes:g:gfm1|GFM1]]|0.56|
|[[:human genes:m:mrps18a|MRPS18A]]|0.559|
|[[:human genes:d:dars2|DARS2]]|0.554|
|[[:human genes:m:mrpl12|MRPL12]]|0.553|
|[[:human genes:b:bcs1l|BCS1L]]|0.55|
|[[:human genes:n:ndufa3|NDUFA3]]|0.547|
|[[:human genes:p:polg2|POLG2]]|0.547|
|[[:human genes:f:ftsj2|FTSJ2]]|0.547|
|[[:human genes:p:pdss1|PDSS1]]|0.547|
|[[:human genes:w:wbscr16|WBSCR16]]|0.545|
|[[:human genes:t:tmem242|TMEM242]]|0.542|
|[[:human genes:a:aars2|AARS2]]|0.54|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.539|
|[[:human genes:l:lsm10|LSM10]]|0.537|
|[[:human genes:m:mrpl47|MRPL47]]|0.535|
|[[:human genes:r:rpia|RPIA]]|0.533|
|[[:human genes:m:mrps14|MRPS14]]|0.531|
|[[:human genes:s:slc25a26|SLC25A26]]|0.529|
|[[:human genes:m:mrps26|MRPS26]]|0.528|
|[[:human genes:d:dnlz|DNLZ]]|0.527|
|[[:human genes:c:c12orf65|C12orf65]]|0.523|
|[[:human genes:n:ndufb5|NDUFB5]]|0.518|
|[[:human genes:g:gfm2|GFM2]]|0.513|
|[[:human genes:s:sars2|SARS2]]|0.513|
|[[:human genes:m:mtg1|MTG1]]|0.512|
|[[:human genes:d:dhrsx|DHRSX]]|0.51|
|[[:human genes:m:mrps24|MRPS24]]|0.509|
|[[:human genes:c:cox7b|COX7B]]|0.509|
|[[:human genes:w:wars2|WARS2]]|0.509|
|[[:human genes:a:atp5a1|ATP5A1]]|0.508|
|[[:human genes:m:mrp63|MRP63]]|0.508|
|[[:human genes:c:c10orf2|C10orf2]]|0.508|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.506|
|[[:human genes:p:pet112|PET112]]|0.506|
|[[:human genes:m:mrps2|MRPS2]]|0.503|
|[[:human genes:m:mrpl15|MRPL15]]|0.502|
|[[:human genes:m:mtg2|MTG2]]|0.501|
|[[:human genes:m:mrps33|MRPS33]]|0.5|
|[[:human genes:t:trmt61a|TRMT61A]]|0.498|
|[[:human genes:c:c17orf89|C17orf89]]|0.497|
|[[:human genes:m:mrps25|MRPS25]]|0.496|
|[[:human genes:a:atp5c1|ATP5C1]]|0.495|
|[[:human genes:m:mrps12|MRPS12]]|0.494|
|[[:human genes:m:mrps35|MRPS35]]|0.492|
|[[:human genes:a:atp5sl|ATP5SL]]|0.491|
|[[:human genes:h:hars2|HARS2]]|0.49|
|[[:human genes:t:tufm|TUFM]]|0.49|
|[[:human genes:m:mrpl34|MRPL34]]|0.49|
|[[:human genes:c:coa6|COA6]]|0.488|
|[[:human genes:n:ndufb6|NDUFB6]]|0.487|
|[[:human genes:r:rpusd3|RPUSD3]]|0.487|
|[[:human genes:t:tmem126b|TMEM126B]]|0.482|
|[[:human genes:p:pgm3|PGM3]]|0.481|
|[[:human genes:g:g6pd|G6PD]]|0.48|
|[[:human genes:c:cox11|COX11]]|0.477|
|[[:human genes:m:mterfd2|MTERFD2]]|0.476|
|[[:human genes:e:ecsit|ECSIT]]|0.474|
|[[:human genes:n:ndufa2|NDUFA2]]|0.474|
|[[:human genes:p:pnpt1|PNPT1]]|0.474|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.473|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.472|
|[[:human genes:m:mrpl45|MRPL45]]|0.47|
|[[:human genes:f:fh|FH]]|0.468|
|[[:human genes:m:mrpl18|MRPL18]]|0.466|
|[[:human genes:n:ndufs7|NDUFS7]]|0.466|
|[[:human genes:m:mettl17|METTL17]]|0.466|
|[[:human genes:a:aifm1|AIFM1]]|0.466|
|[[:human genes:m:mrps10|MRPS10]]|0.465|
|[[:human genes:n:ndufa1|NDUFA1]]|0.463|
|[[:human genes:t:trub2|TRUB2]]|0.462|
|[[:human genes:m:mtif3|MTIF3]]|0.46|
|[[:human genes:c:coa3|COA3]]|0.459|
|[[:human genes:c:coq7|COQ7]]|0.458|
|[[:human genes:n:ndufb9|NDUFB9]]|0.458|
|[[:human genes:a:atp5b|ATP5B]]|0.456|
|[[:human genes:e:elac2|ELAC2]]|0.456|
|[[:human genes:a:atp5o|ATP5O]]|0.455|
|[[:human genes:m:mrpl3|MRPL3]]|0.455|
|[[:human genes:m:mrps11|MRPS11]]|0.454|
|[[:human genes:p:ppa2|PPA2]]|0.454|
|[[:human genes:c:cox17|COX17]]|0.453|
|[[:human genes:a:atp5h|ATP5H]]|0.451|
|[[:human genes:f:fars2|FARS2]]|0.448|
|[[:human genes:t:triap1|TRIAP1]]|0.446|
|[[:human genes:m:mipep|MIPEP]]|0.446|
|[[:human genes:m:mrps9|MRPS9]]|0.445|
|[[:human genes:c:cox5a|COX5A]]|0.445|
|[[:human genes:t:tomm20|TOMM20]]|0.444|
|[[:human genes:n:ndufc2|NDUFC2]]|0.443|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.443|
|[[:human genes:t:trmt10a|TRMT10A]]|0.443|
|[[:human genes:p:pmm2|PMM2]]|0.442|
|[[:human genes:t:tpk1|TPK1]]|0.442|
|[[:human genes:c:cars2|CARS2]]|0.441|
|[[:human genes:a:alg6|ALG6]]|0.44|
|[[:human genes:m:mrpl20|MRPL20]]|0.439|
|[[:human genes:a:atxn10|ATXN10]]|0.437|
|[[:human genes:a:atp5e|ATP5E]]|0.434|
|[[:human genes:t:timm8b|TIMM8B]]|0.432|
|[[:human genes:t:thg1l|THG1L]]|0.432|
|[[:human genes:m:mrpl42|MRPL42]]|0.43|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.43|
|[[:human genes:p:pet117|PET117]]|0.429|
|[[:human genes:f:fam195a|FAM195A]]|0.429|
|[[:human genes:p:pet100|PET100]]|0.428|
|[[:human genes:c:coq3|COQ3]]|0.428|
|[[:human genes:r:rft1|RFT1]]|0.428|
|[[:human genes:p:pmvk|PMVK]]|0.426|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.424|
|[[:human genes:n:ndufb3|NDUFB3]]|0.424|
|[[:human genes:n:ndufa10|NDUFA10]]|0.423|
|[[:human genes:s:slc25a52|SLC25A52]]|0.423|
|[[:human genes:z:zrsr2|ZRSR2]]|0.422|
|[[:human genes:m:mrpl4|MRPL4]]|0.421|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.42|
|[[:human genes:n:ndufs2|NDUFS2]]|0.42|
|[[:human genes:m:mrpl11|MRPL11]]|0.419|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.417|
|[[:human genes:m:mtpap|MTPAP]]|0.417|
|[[:human genes:u:uqcc2|UQCC2]]|0.417|
|[[:human genes:s:srd5a3|SRD5A3]]|0.416|
|[[:human genes:g:grsf1|GRSF1]]|0.415|
|[[:human genes:c:coq2|COQ2]]|0.413|
|[[:human genes:m:mrpl2|MRPL2]]|0.412|
|[[:human genes:t:tomm6|TOMM6]]|0.412|
|[[:human genes:m:mrpl55|MRPL55]]|0.411|
|[[:human genes:m:mrpl22|MRPL22]]|0.41|
|[[:human genes:m:mrps23|MRPS23]]|0.41|
|[[:human genes:p:ppcdc|PPCDC]]|0.409|
|[[:human genes:m:mrps7|MRPS7]]|0.408|
|[[:human genes:d:dhx30|DHX30]]|0.405|
|[[:human genes:m:mrpl33|MRPL33]]|0.405|
|[[:human genes:m:mrpl41|MRPL41]]|0.403|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.401|
|[[:human genes:t:tomm22|TOMM22]]|0.401|
|[[:human genes:n:ndufa11|NDUFA11]]|0.4|
|[[:human genes:t:tfb1m|TFB1M]]|0.4|
|[[:human genes:s:srp14|SRP14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3241
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GATC Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>