======= GBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GBP2
  * **<color #00a2e8>Official Name</color>**: guanylate binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2634|2634]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32456|P32456]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600412|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). {ECO:0000250|UniProtKB:P32455, ECO:0000269|PubMed:8706832}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GBP C|
|GBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|symbiont-containing vacuole membrane|
|defense response to protozoan|
|response to protozoan|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|defense response to Gram-positive bacterium|
|protein localization to nucleus|
|cellular response to interferon-gamma|
|cellular response to interleukin-1|
|response to interferon-gamma|
|response to interleukin-1|
|actin cytoskeleton|
|cellular response to tumor necrosis factor|
|cytoplasmic vesicle|
|response to tumor necrosis factor|
|GTPase activity|
|defense response to bacterium|
|GTP binding|
|Golgi membrane|
|cytokine-mediated signaling pathway|
|response to bacterium|
|perinuclear region of cytoplasm|
|protein localization to organelle|
|innate immune response|
|protein homodimerization activity|
|defense response to other organism|
|Golgi apparatus|
|cellular response to cytokine stimulus|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cellular protein localization|
|cellular macromolecule localization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15736
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GBP2 Expression in NALM6 Cells: 0.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>