======= GCGR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GCGR
  * **<color #00a2e8>Official Name</color>**: glucagon receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2642|2642]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47871|P47871]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GCGR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GCGR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138033|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucagon receptor activity|
|cellular response to glucagon stimulus|
|regulation of glycogen metabolic process|
|response to glucagon|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|regulation of polysaccharide metabolic process|
|guanyl-nucleotide exchange factor activity|
|regulation of glucose metabolic process|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of cellular carbohydrate metabolic process|
|cAMP-mediated signaling|
|regulation of generation of precursor metabolites and energy|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to starvation|
|regulation of carbohydrate metabolic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to nutrient|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|cellular response to peptide hormone stimulus|
|endosome|
|cellular response to peptide|
|second-messenger-mediated signaling|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|response to peptide|
|response to nutrient levels|
|response to extracellular stimulus|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|exocytosis|
|response to hormone|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|secretion|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.29|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.71|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.72|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17708
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GCGR Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>