======= GCN1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GCN1
  * **<color #00a2e8>Official Name</color>**: GCN1 activator of EIF2AK4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10985|10985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92616|Q92616]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GCN1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GCN1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3554|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase regulator activity|
|cellular response to leucine starvation|
|translation factor activity, RNA binding|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|polysome|
|cellular response to amino acid starvation|
|ribosome|
|response to amino acid starvation|
|ribosome binding|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|cellular response to starvation|
|response to starvation|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|cadherin binding|
|cellular response to external stimulus|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|protein kinase binding|
|response to nutrient levels|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|cellular amide metabolic process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of transcription by RNA polymerase II|
|RNA binding|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.05|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.89|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.87|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.71|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.71|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.87|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.87|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.06|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.25|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.32|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.35|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.41|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.45|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.45|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.51|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.76|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.48|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.5|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.52|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.58|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.27|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|4.28|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|6.17|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|7.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif2ak4|EIF2AK4]]|0.593|
|[[:human genes:s:serbp1|SERBP1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 100/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|3/28|
|bone|2/26|
|breast|5/33|
|central nervous system|6/56|
|cervix|3/4|
|colorectal|6/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|6/20|
|lung|3/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2418
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GCN1L1 Expression in NALM6 Cells: 8.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>