======= GCNT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GCNT3
  * **<color #00a2e8>Official Name</color>**: glucosaminyl (N-acetyl) transferase 3, mucin type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9245|9245]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95395|O95395]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GCNT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GCNT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606836|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Branch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immunoglobulin production in mucosal tissue|
|acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|
|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|
|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|mucosal immune response|
|organ or tissue specific immune response|
|intestinal absorption|
|O-glycan processing|
|digestive system process|
|kidney morphogenesis|
|protein O-linked glycosylation|
|digestion|
|immunoglobulin production|
|production of molecular mediator of immune response|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|protein glycosylation|
|macromolecule glycosylation|
|lymphocyte mediated immunity|
|glycosylation|
|kidney development|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|renal system development|
|urogenital system development|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|tissue morphogenesis|
|adaptive immune response|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|leukocyte mediated immunity|
|animal organ morphogenesis|
|carbohydrate derivative metabolic process|
|immune effector process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|immune response|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13122
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GCNT3 Expression in NALM6 Cells: 3.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>