======= GCSH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GCSH
  * **<color #00a2e8>Official Name</color>**: glycine cleavage system protein H
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2653|2653]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23434|P23434]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GCSH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GCSH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/238330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). {ECO:0000269|PubMed:1671321}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GCV H|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycine cleavage complex|
|aminomethyltransferase activity|
|glycine catabolic process|
|glycine decarboxylation via glycine cleavage system|
|protein lipoylation|
|protein-cofactor linkage|
|serine family amino acid catabolic process|
|glycine metabolic process|
|neurotransmitter catabolic process|
|serine family amino acid metabolic process|
|neurotransmitter metabolic process|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|drug catabolic process|
|alpha-amino acid metabolic process|
|protein maturation|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|cellular amino acid metabolic process|
|methylation|
|peptidyl-lysine modification|
|regulation of neurotransmitter levels|
|mitochondrial matrix|
|small molecule catabolic process|
|drug metabolic process|
|peptidyl-amino acid modification|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lipt2|LIPT2]]|0.508|
|[[:human genes:l:lipt1|LIPT1]]|0.498|
|[[:human genes:l:lias|LIAS]]|0.425|
|[[:human genes:s:suclg1|SUCLG1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1880
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GCSH Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>