======= GDF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GDF3
  * **<color #00a2e8>Official Name</color>**: growth differentiation factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9573|9573]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR23|Q9NR23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GDF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GDF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606522|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089). {ECO:0000250|UniProtKB:Q07104, ECO:0000269|PubMed:21805089}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|formation of anatomical boundary|
|primitive streak formation|
|somite rostral/caudal axis specification|
|negative regulation of epidermal cell differentiation|
|negative regulation of epidermis development|
|notochord development|
|negative regulation of myoblast differentiation|
|response to dietary excess|
|gastrulation with mouth forming second|
|regulation of cell fate commitment|
|embryonic axis specification|
|negative regulation of epithelial cell differentiation|
|transforming growth factor beta receptor binding|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of BMP signaling pathway|
|anterior/posterior axis specification|
|regulation of myoblast differentiation|
|SMAD protein signal transduction|
|regulation of epidermal cell differentiation|
|positive regulation of fat cell differentiation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|embryonic pattern specification|
|somitogenesis|
|endoderm development|
|somite development|
|axis specification|
|regulation of epidermis development|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|segmentation|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of fat cell differentiation|
|mesoderm development|
|regulation of epithelial cell differentiation|
|negative regulation of cellular response to growth factor stimulus|
|gastrulation|
|growth factor activity|
|cytokine activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|anterior/posterior pattern specification|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|regionalization|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|embryonic organ development|
|pattern specification process|
|protein kinase binding|
|skeletal system development|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to growth factor|
|response to extracellular stimulus|
|sensory organ development|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GDF3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>