======= GEMIN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GEMIN4
  * **<color #00a2e8>Official Name</color>**: gem nuclear organelle associated protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50628|50628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57678|P57678]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GEMIN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GEMIN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606969|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:18984161}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SMN complex|
|Gemini of coiled bodies|
|small nuclear ribonucleoprotein complex|
|SMN-Sm protein complex|
|spliceosomal snRNP assembly|
|import into nucleus|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear body|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|ribosome biogenesis|
|RNA splicing, via transesterification reactions|
|ncRNA processing|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|intracellular transport|
|protein-containing complex assembly|
|RNA metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.14|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.06|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.92|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.483|
|[[:human genes:g:gemin6|GEMIN6]]|0.47|
|[[:human genes:p:ppa1|PPA1]]|0.461|
|[[:human genes:c:c15orf41|C15orf41]]|0.438|
|[[:human genes:s:snapc5|SNAPC5]]|0.435|
|[[:human genes:p:pmvk|PMVK]]|0.435|
|[[:human genes:p:ppp6c|PPP6C]]|0.433|
|[[:human genes:d:ddx39a|DDX39A]]|0.432|
|[[:human genes:p:ppcdc|PPCDC]]|0.414|
|[[:human genes:g:gemin7|GEMIN7]]|0.412|
|[[:human genes:p:ppcs|PPCS]]|0.41|
|[[:human genes:p:ptar1|PTAR1]]|0.409|
|[[:human genes:r:rpia|RPIA]]|0.407|
|[[:human genes:t:ten1|TEN1]]|0.401|
|[[:human genes:t:taf1a|TAF1A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 208/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|8/28|
|bone|7/26|
|breast|9/33|
|central nervous system|15/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|2/21|
|liver|4/20|
|lung|23/75|
|lymphocyte|5/16|
|ovary|9/26|
|pancreas|14/24|
|peripheral nervous system|3/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|15/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1245
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GEMIN4 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>