======= GEMIN7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GEMIN7
  * **<color #00a2e8>Official Name</color>**: gem nuclear organelle associated protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79760|79760]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H840|Q9H840]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GEMIN7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GEMIN7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607419|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gemin7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SMN complex|
|Gemini of coiled bodies|
|SMN-Sm protein complex|
|spliceosomal snRNP assembly|
|import into nucleus|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear body|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|intracellular transport|
|protein-containing complex assembly|
|RNA metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.88|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.8|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.71|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.76|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.78|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.79|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.81|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.99|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.01|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.08|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.17|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.18|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.19|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.33|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.33|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.44|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.55|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.619|
|[[:human genes:g:gemin6|GEMIN6]]|0.608|
|[[:human genes:t:thg1l|THG1L]]|0.593|
|[[:human genes:f:fh|FH]]|0.554|
|[[:human genes:r:rpp21|RPP21]]|0.55|
|[[:human genes:t:tbcb|TBCB]]|0.544|
|[[:human genes:r:rpia|RPIA]]|0.543|
|[[:human genes:v:vezt|VEZT]]|0.543|
|[[:human genes:t:ten1|TEN1]]|0.53|
|[[:human genes:d:dhrsx|DHRSX]]|0.51|
|[[:human genes:c:cep57|CEP57]]|0.5|
|[[:human genes:p:ppp6c|PPP6C]]|0.499|
|[[:human genes:a:alg13|ALG13]]|0.497|
|[[:human genes:m:msto1|MSTO1]]|0.494|
|[[:human genes:a:atxn10|ATXN10]]|0.491|
|[[:human genes:a:alg1|ALG1]]|0.489|
|[[:human genes:c:chchd4|CHCHD4]]|0.489|
|[[:human genes:z:zrsr2|ZRSR2]]|0.488|
|[[:human genes:r:rabggtb|RABGGTB]]|0.488|
|[[:human genes:l:lsm10|LSM10]]|0.487|
|[[:human genes:u:uap1|UAP1]]|0.486|
|[[:human genes:s:srp14|SRP14]]|0.486|
|[[:human genes:d:dr1|DR1]]|0.483|
|[[:human genes:c:cxorf56|CXorf56]]|0.482|
|[[:human genes:d:ddx39a|DDX39A]]|0.48|
|[[:human genes:z:znhit1|ZNHIT1]]|0.477|
|[[:human genes:g:gmppb|GMPPB]]|0.476|
|[[:human genes:c:c15orf41|C15orf41]]|0.475|
|[[:human genes:a:adsl|ADSL]]|0.473|
|[[:human genes:t:triap1|TRIAP1]]|0.473|
|[[:human genes:t:txnl4b|TXNL4B]]|0.472|
|[[:human genes:u:uhrf1|UHRF1]]|0.47|
|[[:human genes:p:pgm3|PGM3]]|0.468|
|[[:human genes:p:ppcs|PPCS]]|0.468|
|[[:human genes:t:tpk1|TPK1]]|0.466|
|[[:human genes:p:ppcdc|PPCDC]]|0.466|
|[[:human genes:d:dnlz|DNLZ]]|0.466|
|[[:human genes:s:snapc5|SNAPC5]]|0.465|
|[[:human genes:t:tmem242|TMEM242]]|0.465|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.464|
|[[:human genes:d:ddx20|DDX20]]|0.462|
|[[:human genes:c:c1d|C1D]]|0.461|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.461|
|[[:human genes:c:ctc1|CTC1]]|0.46|
|[[:human genes:p:pmvk|PMVK]]|0.458|
|[[:human genes:w:wdr92|WDR92]]|0.457|
|[[:human genes:n:n6amt1|N6AMT1]]|0.453|
|[[:human genes:z:zcrb1|ZCRB1]]|0.453|
|[[:human genes:c:c11orf57|C11orf57]]|0.452|
|[[:human genes:n:nbn|NBN]]|0.452|
|[[:human genes:r:rft1|RFT1]]|0.451|
|[[:human genes:d:ddx55|DDX55]]|0.451|
|[[:human genes:t:trmt61a|TRMT61A]]|0.45|
|[[:human genes:p:ppa2|PPA2]]|0.448|
|[[:human genes:t:taf1a|TAF1A]]|0.446|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.442|
|[[:human genes:e:elac2|ELAC2]]|0.441|
|[[:human genes:t:ttc4|TTC4]]|0.441|
|[[:human genes:m:mrps5|MRPS5]]|0.44|
|[[:human genes:p:ptar1|PTAR1]]|0.439|
|[[:human genes:t:tsen54|TSEN54]]|0.436|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.436|
|[[:human genes:u:uxt|UXT]]|0.434|
|[[:human genes:d:dpagt1|DPAGT1]]|0.434|
|[[:human genes:u:urm1|URM1]]|0.43|
|[[:human genes:p:pmm2|PMM2]]|0.43|
|[[:human genes:b:bcs1l|BCS1L]]|0.43|
|[[:human genes:e:exoc3|EXOC3]]|0.429|
|[[:human genes:r:rpe|RPE]]|0.429|
|[[:human genes:p:pdcd5|PDCD5]]|0.429|
|[[:human genes:c:c17orf89|C17orf89]]|0.426|
|[[:human genes:t:tamm41|TAMM41]]|0.425|
|[[:human genes:c:c12orf65|C12orf65]]|0.422|
|[[:human genes:d:dolk|DOLK]]|0.421|
|[[:human genes:t:tprkb|TPRKB]]|0.421|
|[[:human genes:h:hccs|HCCS]]|0.421|
|[[:human genes:d:dohh|DOHH]]|0.42|
|[[:human genes:f:fen1|FEN1]]|0.419|
|[[:human genes:e:exoc4|EXOC4]]|0.416|
|[[:human genes:c:camlg|CAMLG]]|0.416|
|[[:human genes:p:pggt1b|PGGT1B]]|0.416|
|[[:human genes:r:rptor|RPTOR]]|0.415|
|[[:human genes:t:trmt6|TRMT6]]|0.415|
|[[:human genes:u:utp23|UTP23]]|0.414|
|[[:human genes:s:slc25a26|SLC25A26]]|0.414|
|[[:human genes:b:bak1|BAK1]]|0.414|
|[[:human genes:a:atic|ATIC]]|0.413|
|[[:human genes:g:gemin4|GEMIN4]]|0.412|
|[[:human genes:f:fastkd5|FASTKD5]]|0.41|
|[[:human genes:m:mrpl21|MRPL21]]|0.408|
|[[:human genes:g:gfpt1|GFPT1]]|0.407|
|[[:human genes:s:ssb|SSB]]|0.407|
|[[:human genes:m:mettl14|METTL14]]|0.407|
|[[:human genes:p:ppa1|PPA1]]|0.407|
|[[:human genes:s:slc25a19|SLC25A19]]|0.406|
|[[:human genes:e:eif3f|EIF3F]]|0.405|
|[[:human genes:y:yars2|YARS2]]|0.405|
|[[:human genes:e:ercc2|ERCC2]]|0.403|
|[[:human genes:s:srd5a3|SRD5A3]]|0.402|
|[[:human genes:n:nae1|NAE1]]|0.402|
|[[:human genes:p:pdss1|PDSS1]]|0.402|
|[[:human genes:p:pik3r4|PIK3R4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7464
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GEMIN7 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>