======= GEMIN8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GEMIN8
  * **<color #00a2e8>Official Name</color>**: gem nuclear organelle associated protein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54960|54960]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWZ8|Q9NWZ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GEMIN8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GEMIN8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300962|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SMN complex|
|Gemini of coiled bodies|
|SMN-Sm protein complex|
|spliceosomal snRNP assembly|
|import into nucleus|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|intracellular transport|
|protein-containing complex assembly|
|RNA metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2.5|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.15|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.12|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.08|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.05|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.96|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.92|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.88|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.84|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.83|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.8|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.73|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.73|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.73|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.85|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin6|GEMIN6]]|0.685|
|[[:human genes:c:c15orf41|C15orf41]]|0.622|
|[[:human genes:g:gemin7|GEMIN7]]|0.619|
|[[:human genes:t:ten1|TEN1]]|0.607|
|[[:human genes:r:rabggtb|RABGGTB]]|0.602|
|[[:human genes:a:alg1|ALG1]]|0.6|
|[[:human genes:r:rpp21|RPP21]]|0.594|
|[[:human genes:t:thg1l|THG1L]]|0.592|
|[[:human genes:v:vezt|VEZT]]|0.586|
|[[:human genes:s:snapc5|SNAPC5]]|0.581|
|[[:human genes:a:atxn10|ATXN10]]|0.569|
|[[:human genes:r:rpia|RPIA]]|0.567|
|[[:human genes:s:srp14|SRP14]]|0.561|
|[[:human genes:p:pmm2|PMM2]]|0.56|
|[[:human genes:z:zrsr2|ZRSR2]]|0.551|
|[[:human genes:t:tbcb|TBCB]]|0.542|
|[[:human genes:d:ddx20|DDX20]]|0.539|
|[[:human genes:n:nsmce1|NSMCE1]]|0.539|
|[[:human genes:f:fh|FH]]|0.538|
|[[:human genes:c:ctc1|CTC1]]|0.538|
|[[:human genes:a:adsl|ADSL]]|0.537|
|[[:human genes:p:ppcs|PPCS]]|0.537|
|[[:human genes:n:n6amt1|N6AMT1]]|0.534|
|[[:human genes:g:gmppb|GMPPB]]|0.532|
|[[:human genes:a:atic|ATIC]]|0.53|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.53|
|[[:human genes:m:msto1|MSTO1]]|0.529|
|[[:human genes:p:ppp6c|PPP6C]]|0.528|
|[[:human genes:u:uhrf1|UHRF1]]|0.527|
|[[:human genes:p:ppp4c|PPP4C]]|0.526|
|[[:human genes:a:alg13|ALG13]]|0.523|
|[[:human genes:r:rtcb|RTCB]]|0.519|
|[[:human genes:d:dpagt1|DPAGT1]]|0.517|
|[[:human genes:d:ddx55|DDX55]]|0.511|
|[[:human genes:t:tbca|TBCA]]|0.507|
|[[:human genes:c:cep57|CEP57]]|0.505|
|[[:human genes:l:lsm10|LSM10]]|0.505|
|[[:human genes:w:wdr92|WDR92]]|0.496|
|[[:human genes:r:rfk|RFK]]|0.493|
|[[:human genes:u:uap1|UAP1]]|0.493|
|[[:human genes:d:ddx39a|DDX39A]]|0.493|
|[[:human genes:z:znhit1|ZNHIT1]]|0.492|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.489|
|[[:human genes:r:rad50|RAD50]]|0.489|
|[[:human genes:s:slc25a19|SLC25A19]]|0.488|
|[[:human genes:t:tsen54|TSEN54]]|0.487|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.486|
|[[:human genes:t:taf1a|TAF1A]]|0.484|
|[[:human genes:g:gemin4|GEMIN4]]|0.483|
|[[:human genes:p:ppcdc|PPCDC]]|0.482|
|[[:human genes:t:ttc4|TTC4]]|0.48|
|[[:human genes:t:triap1|TRIAP1]]|0.48|
|[[:human genes:g:ggps1|GGPS1]]|0.479|
|[[:human genes:c:c14orf80|C14orf80]]|0.478|
|[[:human genes:n:nae1|NAE1]]|0.477|
|[[:human genes:g:gnb1l|GNB1L]]|0.476|
|[[:human genes:r:rft1|RFT1]]|0.475|
|[[:human genes:t:tpi1|TPI1]]|0.475|
|[[:human genes:t:tprkb|TPRKB]]|0.471|
|[[:human genes:d:dr1|DR1]]|0.471|
|[[:human genes:t:tamm41|TAMM41]]|0.471|
|[[:human genes:t:tpk1|TPK1]]|0.47|
|[[:human genes:t:tubd1|TUBD1]]|0.467|
|[[:human genes:m:mettl14|METTL14]]|0.467|
|[[:human genes:e:exoc4|EXOC4]]|0.467|
|[[:human genes:z:zcrb1|ZCRB1]]|0.465|
|[[:human genes:e:eno1|ENO1]]|0.465|
|[[:human genes:e:eif3f|EIF3F]]|0.464|
|[[:human genes:s:srd5a3|SRD5A3]]|0.462|
|[[:human genes:p:ptar1|PTAR1]]|0.46|
|[[:human genes:r:rpe|RPE]]|0.46|
|[[:human genes:f:fen1|FEN1]]|0.459|
|[[:human genes:k:kdm8|KDM8]]|0.459|
|[[:human genes:c:cenpa|CENPA]]|0.458|
|[[:human genes:d:dhrsx|DHRSX]]|0.456|
|[[:human genes:e:eprs|EPRS]]|0.454|
|[[:human genes:c:chchd4|CHCHD4]]|0.454|
|[[:human genes:w:wdr1|WDR1]]|0.453|
|[[:human genes:u:urm1|URM1]]|0.453|
|[[:human genes:t:tti2|TTI2]]|0.451|
|[[:human genes:u:uxt|UXT]]|0.45|
|[[:human genes:o:osgep|OSGEP]]|0.448|
|[[:human genes:n:nbn|NBN]]|0.447|
|[[:human genes:m:med16|MED16]]|0.447|
|[[:human genes:r:rad1|RAD1]]|0.446|
|[[:human genes:p:pelo|PELO]]|0.446|
|[[:human genes:e:exoc3|EXOC3]]|0.445|
|[[:human genes:p:pgk1|PGK1]]|0.443|
|[[:human genes:d:dctn6|DCTN6]]|0.442|
|[[:human genes:g:gfpt1|GFPT1]]|0.441|
|[[:human genes:r:rnmt|RNMT]]|0.441|
|[[:human genes:p:pgm3|PGM3]]|0.441|
|[[:human genes:f:fntb|FNTB]]|0.44|
|[[:human genes:f:fnta|FNTA]]|0.44|
|[[:human genes:d:dohh|DOHH]]|0.439|
|[[:human genes:t:trmt5|TRMT5]]|0.439|
|[[:human genes:d:dnlz|DNLZ]]|0.438|
|[[:human genes:d:dolk|DOLK]]|0.438|
|[[:human genes:r:rptor|RPTOR]]|0.438|
|[[:human genes:r:rbbp4|RBBP4]]|0.433|
|[[:human genes:h:haus8|HAUS8]]|0.432|
|[[:human genes:u:utp23|UTP23]]|0.431|
|[[:human genes:p:ppa1|PPA1]]|0.43|
|[[:human genes:x:xrcc2|XRCC2]]|0.43|
|[[:human genes:g:gemin5|GEMIN5]]|0.429|
|[[:human genes:t:trmt61a|TRMT61A]]|0.427|
|[[:human genes:b:bub3|BUB3]]|0.426|
|[[:human genes:g:gpn2|GPN2]]|0.425|
|[[:human genes:s:slc25a26|SLC25A26]]|0.423|
|[[:human genes:c:cdipt|CDIPT]]|0.423|
|[[:human genes:s:sugt1|SUGT1]]|0.418|
|[[:human genes:o:oip5|OIP5]]|0.418|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.417|
|[[:human genes:d:ddx1|DDX1]]|0.416|
|[[:human genes:t:trmt6|TRMT6]]|0.414|
|[[:human genes:t:trnt1|TRNT1]]|0.414|
|[[:human genes:t:tsen34|TSEN34]]|0.414|
|[[:human genes:s:ssb|SSB]]|0.413|
|[[:human genes:n:ndor1|NDOR1]]|0.412|
|[[:human genes:e:elp2|ELP2]]|0.412|
|[[:human genes:l:lsm11|LSM11]]|0.412|
|[[:human genes:m:mars|MARS]]|0.411|
|[[:human genes:h:hars|HARS]]|0.41|
|[[:human genes:w:wrb|WRB]]|0.409|
|[[:human genes:t:tkt|TKT]]|0.408|
|[[:human genes:s:snf8|SNF8]]|0.407|
|[[:human genes:t:tube1|TUBE1]]|0.407|
|[[:human genes:t:telo2|TELO2]]|0.405|
|[[:human genes:u:uba3|UBA3]]|0.404|
|[[:human genes:t:tmem242|TMEM242]]|0.404|
|[[:human genes:e:elp3|ELP3]]|0.403|
|[[:human genes:p:pmvk|PMVK]]|0.402|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 110/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|1/26|
|bone|5/26|
|breast|4/30|
|central nervous system|7/49|
|cervix|0/4|
|colorectal|5/17|
|esophagus|3/11|
|fibroblast|1/1|
|gastric|2/14|
|kidney|0/18|
|liver|2/19|
|lung|11/72|
|lymphocyte|1/16|
|ovary|7/25|
|pancreas|5/22|
|peripheral nervous system|1/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|4/20|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|6/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1739
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GEMIN8 Expression in NALM6 Cells: 3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>