======= GFM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GFM1
  * **<color #00a2e8>Official Name</color>**: G elongation factor mitochondrial 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85476|85476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RP9|Q96RP9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GFM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GFM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606639|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03061, ECO:0000269|PubMed:19716793}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EFG IV|
|EFG C|
|GTP EFTU|
|GTP EFTU D2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation elongation factor activity|
|mitochondrial translational elongation|
|mitochondrial translation|
|translational elongation|
|mitochondrial gene expression|
|GTPase activity|
|mitochondrial matrix|
|translation|
|GTP binding|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.91|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.77|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.76|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.7|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.74|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.77|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.77|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.82|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.84|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.86|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.88|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.9|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.93|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.94|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.01|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.03|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.27|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.28|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.39|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.46|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.57|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.73|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.763|
|[[:human genes:t:tars2|TARS2]]|0.732|
|[[:human genes:n:nars2|NARS2]]|0.731|
|[[:human genes:y:yars2|YARS2]]|0.718|
|[[:human genes:d:dars2|DARS2]]|0.714|
|[[:human genes:m:mrps6|MRPS6]]|0.712|
|[[:human genes:m:mrps21|MRPS21]]|0.697|
|[[:human genes:m:mrps14|MRPS14]]|0.695|
|[[:human genes:s:sco2|SCO2]]|0.694|
|[[:human genes:m:mrpl21|MRPL21]]|0.692|
|[[:human genes:m:mrps16|MRPS16]]|0.687|
|[[:human genes:v:vars2|VARS2]]|0.686|
|[[:human genes:d:dap3|DAP3]]|0.685|
|[[:human genes:b:bcs1l|BCS1L]]|0.677|
|[[:human genes:l:lars2|LARS2]]|0.666|
|[[:human genes:m:mrps34|MRPS34]]|0.666|
|[[:human genes:r:rpusd4|RPUSD4]]|0.663|
|[[:human genes:m:mrp63|MRP63]]|0.661|
|[[:human genes:t:tufm|TUFM]]|0.66|
|[[:human genes:r:rars2|RARS2]]|0.658|
|[[:human genes:s:selrc1|SELRC1]]|0.657|
|[[:human genes:p:pars2|PARS2]]|0.657|
|[[:human genes:w:wbscr16|WBSCR16]]|0.654|
|[[:human genes:m:mrpl53|MRPL53]]|0.651|
|[[:human genes:r:rbfa|RBFA]]|0.651|
|[[:human genes:m:mrpl23|MRPL23]]|0.647|
|[[:human genes:e:ears2|EARS2]]|0.643|
|[[:human genes:n:ndufa3|NDUFA3]]|0.641|
|[[:human genes:m:mrps26|MRPS26]]|0.64|
|[[:human genes:m:mrps5|MRPS5]]|0.639|
|[[:human genes:m:mrpl45|MRPL45]]|0.638|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.636|
|[[:human genes:c:cox16|COX16]]|0.631|
|[[:human genes:c:c10orf2|C10orf2]]|0.629|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.628|
|[[:human genes:n:ndufb11|NDUFB11]]|0.627|
|[[:human genes:q:qrsl1|QRSL1]]|0.626|
|[[:human genes:m:mars2|MARS2]]|0.626|
|[[:human genes:a:aars2|AARS2]]|0.619|
|[[:human genes:p:pnpt1|PNPT1]]|0.611|
|[[:human genes:m:mrps18a|MRPS18A]]|0.61|
|[[:human genes:c:c12orf65|C12orf65]]|0.61|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.608|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.607|
|[[:human genes:t:tfam|TFAM]]|0.606|
|[[:human genes:f:ftsj2|FTSJ2]]|0.603|
|[[:human genes:m:mrpl47|MRPL47]]|0.601|
|[[:human genes:g:gfm2|GFM2]]|0.6|
|[[:human genes:f:fars2|FARS2]]|0.597|
|[[:human genes:c:cox15|COX15]]|0.595|
|[[:human genes:f:fastkd5|FASTKD5]]|0.595|
|[[:human genes:s:sars2|SARS2]]|0.594|
|[[:human genes:m:mrpl12|MRPL12]]|0.592|
|[[:human genes:t:tefm|TEFM]]|0.592|
|[[:human genes:p:polg2|POLG2]]|0.591|
|[[:human genes:m:mrps9|MRPS9]]|0.59|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.587|
|[[:human genes:m:mrps25|MRPS25]]|0.586|
|[[:human genes:m:mrpl3|MRPL3]]|0.585|
|[[:human genes:m:mrps33|MRPS33]]|0.583|
|[[:human genes:c:coa3|COA3]]|0.583|
|[[:human genes:m:mrps2|MRPS2]]|0.582|
|[[:human genes:n:ndufc2|NDUFC2]]|0.582|
|[[:human genes:h:hars2|HARS2]]|0.581|
|[[:human genes:n:ndufa1|NDUFA1]]|0.581|
|[[:human genes:n:ndufb5|NDUFB5]]|0.578|
|[[:human genes:m:mrpl20|MRPL20]]|0.578|
|[[:human genes:m:mrps11|MRPS11]]|0.578|
|[[:human genes:r:rpusd3|RPUSD3]]|0.575|
|[[:human genes:m:mtg2|MTG2]]|0.572|
|[[:human genes:m:mrpl15|MRPL15]]|0.567|
|[[:human genes:m:mrps23|MRPS23]]|0.566|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.564|
|[[:human genes:s:slc25a26|SLC25A26]]|0.56|
|[[:human genes:g:gatc|GATC]]|0.56|
|[[:human genes:a:aifm1|AIFM1]]|0.556|
|[[:human genes:c:cox7b|COX7B]]|0.554|
|[[:human genes:p:polg|POLG]]|0.553|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.549|
|[[:human genes:p:pet112|PET112]]|0.548|
|[[:human genes:c:cox17|COX17]]|0.547|
|[[:human genes:n:ndufs2|NDUFS2]]|0.543|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.542|
|[[:human genes:a:atp5c1|ATP5C1]]|0.541|
|[[:human genes:m:mrps12|MRPS12]]|0.539|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.538|
|[[:human genes:t:tfb1m|TFB1M]]|0.535|
|[[:human genes:c:coa6|COA6]]|0.534|
|[[:human genes:m:mrps24|MRPS24]]|0.534|
|[[:human genes:m:mrps10|MRPS10]]|0.531|
|[[:human genes:e:ecsit|ECSIT]]|0.531|
|[[:human genes:n:ndufa2|NDUFA2]]|0.53|
|[[:human genes:m:mrps22|MRPS22]]|0.529|
|[[:human genes:t:tomm20|TOMM20]]|0.528|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.528|
|[[:human genes:m:mrps7|MRPS7]]|0.528|
|[[:human genes:n:ndufb6|NDUFB6]]|0.528|
|[[:human genes:m:mrpl55|MRPL55]]|0.527|
|[[:human genes:m:mettl17|METTL17]]|0.526|
|[[:human genes:m:mtg1|MTG1]]|0.524|
|[[:human genes:m:mrpl43|MRPL43]]|0.523|
|[[:human genes:c:coq2|COQ2]]|0.522|
|[[:human genes:w:wars2|WARS2]]|0.522|
|[[:human genes:c:cars2|CARS2]]|0.519|
|[[:human genes:m:mrpl44|MRPL44]]|0.519|
|[[:human genes:a:atp5sl|ATP5SL]]|0.517|
|[[:human genes:p:pgm3|PGM3]]|0.515|
|[[:human genes:p:pdss1|PDSS1]]|0.515|
|[[:human genes:m:mrpl42|MRPL42]]|0.515|
|[[:human genes:m:mterfd1|MTERFD1]]|0.514|
|[[:human genes:t:trub2|TRUB2]]|0.512|
|[[:human genes:g:grsf1|GRSF1]]|0.511|
|[[:human genes:m:mtpap|MTPAP]]|0.511|
|[[:human genes:c:cox6c|COX6C]]|0.51|
|[[:human genes:p:pet117|PET117]]|0.509|
|[[:human genes:e:elac2|ELAC2]]|0.508|
|[[:human genes:n:ndufb3|NDUFB3]]|0.508|
|[[:human genes:c:c17orf89|C17orf89]]|0.506|
|[[:human genes:c:coq7|COQ7]]|0.505|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.504|
|[[:human genes:c:chchd1|CHCHD1]]|0.503|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.503|
|[[:human genes:t:tomm22|TOMM22]]|0.502|
|[[:human genes:i:iba57|IBA57]]|0.502|
|[[:human genes:m:mrpl39|MRPL39]]|0.501|
|[[:human genes:c:coq6|COQ6]]|0.501|
|[[:human genes:m:mrpl11|MRPL11]]|0.501|
|[[:human genes:a:atp5a1|ATP5A1]]|0.499|
|[[:human genes:c:cox11|COX11]]|0.498|
|[[:human genes:m:malsu1|MALSU1]]|0.497|
|[[:human genes:m:mrpl18|MRPL18]]|0.497|
|[[:human genes:m:mrpl28|MRPL28]]|0.496|
|[[:human genes:n:ndufa10|NDUFA10]]|0.494|
|[[:human genes:a:atp5d|ATP5D]]|0.491|
|[[:human genes:f:fastkd2|FASTKD2]]|0.49|
|[[:human genes:c:chchd4|CHCHD4]]|0.49|
|[[:human genes:d:dhrsx|DHRSX]]|0.488|
|[[:human genes:m:mrps27|MRPS27]]|0.488|
|[[:human genes:m:mrpl52|MRPL52]]|0.488|
|[[:human genes:d:dhx30|DHX30]]|0.487|
|[[:human genes:m:mrps17|MRPS17]]|0.487|
|[[:human genes:n:ndufb9|NDUFB9]]|0.487|
|[[:human genes:m:mrpl33|MRPL33]]|0.483|
|[[:human genes:t:tmem242|TMEM242]]|0.481|
|[[:human genes:m:mrps35|MRPS35]]|0.479|
|[[:human genes:m:mipep|MIPEP]]|0.479|
|[[:human genes:t:triap1|TRIAP1]]|0.478|
|[[:human genes:m:mto1|MTO1]]|0.478|
|[[:human genes:n:ndufs5|NDUFS5]]|0.478|
|[[:human genes:p:polrmt|POLRMT]]|0.478|
|[[:human genes:n:ndufa11|NDUFA11]]|0.477|
|[[:human genes:n:ndufv1|NDUFV1]]|0.477|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.477|
|[[:human genes:m:mrps28|MRPS28]]|0.476|
|[[:human genes:m:mrpl4|MRPL4]]|0.475|
|[[:human genes:t:trmt10c|TRMT10C]]|0.475|
|[[:human genes:t:tomm7|TOMM7]]|0.473|
|[[:human genes:a:acad9|ACAD9]]|0.473|
|[[:human genes:c:coq3|COQ3]]|0.472|
|[[:human genes:p:ppa2|PPA2]]|0.469|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.469|
|[[:human genes:c:coa5|COA5]]|0.468|
|[[:human genes:t:tomm40|TOMM40]]|0.468|
|[[:human genes:m:mcat|MCAT]]|0.468|
|[[:human genes:m:mrpl36|MRPL36]]|0.467|
|[[:human genes:t:tmem261|TMEM261]]|0.467|
|[[:human genes:m:mrpl51|MRPL51]]|0.464|
|[[:human genes:n:nfu1|NFU1]]|0.463|
|[[:human genes:s:ssbp1|SSBP1]]|0.463|
|[[:human genes:a:atp5b|ATP5B]]|0.462|
|[[:human genes:s:slc25a3|SLC25A3]]|0.461|
|[[:human genes:a:alg6|ALG6]]|0.459|
|[[:human genes:c:coq4|COQ4]]|0.459|
|[[:human genes:m:mrpl35|MRPL35]]|0.459|
|[[:human genes:m:mrpl13|MRPL13]]|0.458|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.457|
|[[:human genes:c:coq5|COQ5]]|0.456|
|[[:human genes:m:mrpl38|MRPL38]]|0.454|
|[[:human genes:u:uqcr10|UQCR10]]|0.453|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.453|
|[[:human genes:t:timm8b|TIMM8B]]|0.453|
|[[:human genes:l:lsm10|LSM10]]|0.452|
|[[:human genes:n:ndufs7|NDUFS7]]|0.452|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.452|
|[[:human genes:m:mrpl37|MRPL37]]|0.451|
|[[:human genes:a:atp5h|ATP5H]]|0.451|
|[[:human genes:l:lrpprc|LRPPRC]]|0.45|
|[[:human genes:m:mtif2|MTIF2]]|0.449|
|[[:human genes:m:mrpl32|MRPL32]]|0.449|
|[[:human genes:c:cox20|COX20]]|0.449|
|[[:human genes:h:higd2a|HIGD2A]]|0.448|
|[[:human genes:t:tomm6|TOMM6]]|0.446|
|[[:human genes:m:mrpl1|MRPL1]]|0.444|
|[[:human genes:m:mrpl17|MRPL17]]|0.443|
|[[:human genes:c:clpp|CLPP]]|0.441|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.441|
|[[:human genes:h:hccs|HCCS]]|0.441|
|[[:human genes:m:mterfd2|MTERFD2]]|0.441|
|[[:human genes:m:mrpl49|MRPL49]]|0.438|
|[[:human genes:m:mrpl34|MRPL34]]|0.438|
|[[:human genes:d:dnlz|DNLZ]]|0.437|
|[[:human genes:c:crls1|CRLS1]]|0.435|
|[[:human genes:m:mrpl46|MRPL46]]|0.435|
|[[:human genes:c:c1qbp|C1QBP]]|0.435|
|[[:human genes:f:fh|FH]]|0.435|
|[[:human genes:m:mrps18b|MRPS18B]]|0.435|
|[[:human genes:r:rpia|RPIA]]|0.433|
|[[:human genes:s:slc25a19|SLC25A19]]|0.432|
|[[:human genes:f:fastkd1|FASTKD1]]|0.431|
|[[:human genes:f:foxred1|FOXRED1]]|0.431|
|[[:human genes:e:eral1|ERAL1]]|0.428|
|[[:human genes:n:ndufa6|NDUFA6]]|0.427|
|[[:human genes:n:ndufc1|NDUFC1]]|0.427|
|[[:human genes:a:alas1|ALAS1]]|0.427|
|[[:human genes:n:ndufs8|NDUFS8]]|0.427|
|[[:human genes:a:atp5e|ATP5E]]|0.427|
|[[:human genes:n:ndufa8|NDUFA8]]|0.427|
|[[:human genes:n:nubpl|NUBPL]]|0.427|
|[[:human genes:t:tmem126b|TMEM126B]]|0.427|
|[[:human genes:p:ptcd3|PTCD3]]|0.426|
|[[:human genes:a:atxn10|ATXN10]]|0.425|
|[[:human genes:m:mrpl22|MRPL22]]|0.425|
|[[:human genes:p:pmm2|PMM2]]|0.423|
|[[:human genes:d:dpagt1|DPAGT1]]|0.421|
|[[:human genes:a:atp5j|ATP5J]]|0.421|
|[[:human genes:u:uqcc2|UQCC2]]|0.42|
|[[:human genes:c:cox5a|COX5A]]|0.418|
|[[:human genes:n:nsun4|NSUN4]]|0.416|
|[[:human genes:m:mrpl2|MRPL2]]|0.416|
|[[:human genes:n:ndufb4|NDUFB4]]|0.416|
|[[:human genes:a:atp5o|ATP5O]]|0.415|
|[[:human genes:n:ndufa5|NDUFA5]]|0.415|
|[[:human genes:a:atic|ATIC]]|0.412|
|[[:human genes:m:mtif3|MTIF3]]|0.411|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.41|
|[[:human genes:p:pet100|PET100]]|0.408|
|[[:human genes:s:sco1|SCO1]]|0.408|
|[[:human genes:c:cycs|CYCS]]|0.408|
|[[:human genes:d:dolk|DOLK]]|0.406|
|[[:human genes:d:ddx28|DDX28]]|0.406|
|[[:human genes:g:glrx5|GLRX5]]|0.405|
|[[:human genes:n:nsun2|NSUN2]]|0.403|
|[[:human genes:t:timm21|TIMM21]]|0.402|
|[[:human genes:a:angel2|ANGEL2]]|0.401|
|[[:human genes:p:prkrir|PRKRIR]]|0.401|
|[[:human genes:u:uhrf1|UHRF1]]|0.401|
|[[:human genes:s:srd5a3|SRD5A3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 54/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|6/33|
|central nervous system|4/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 328
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GFM1 Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>