======= GFRAL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GFRAL
  * **<color #00a2e8>Official Name</color>**: GDNF family receptor alpha like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=389400|389400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXV0|Q6UXV0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GFRAL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GFRAL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GDNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glial cell-derived neurotrophic factor receptor activity|
|reduction of food intake in response to dietary excess|
|glial cell-derived neurotrophic factor receptor signaling pathway|
|response to dietary excess|
|eating behavior|
|negative regulation of signal transduction in absence of ligand|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|receptor tyrosine kinase binding|
|feeding behavior|
|negative regulation of extrinsic apoptotic signaling pathway|
|stress-activated protein kinase signaling cascade|
|negative regulation of neuron apoptotic process|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|positive regulation of protein kinase B signaling|
|receptor complex|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of protein kinase B signaling|
|negative regulation of apoptotic signaling pathway|
|positive regulation of MAP kinase activity|
|regulation of neuron death|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|external side of plasma membrane|
|regulation of apoptotic signaling pathway|
|response to nutrient levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|behavior|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of transferase activity|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.71|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GFRAL Expression in NALM6 Cells: 1.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>