======= GGA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGA1
  * **<color #00a2e8>Official Name</color>**: golgi associated, gamma adaptin ear containing, ARF binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26088|26088]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJY5|Q9UJY5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606004|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VHS|
|GAT|
|Alpha adaptinC2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ADP-ribosylation factor binding|
|protein localization to ciliary membrane|
|protein localization to cell surface|
|Golgi to plasma membrane protein transport|
|toxin transport|
|protein localization to cilium|
|establishment of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|vesicle-mediated transport to the plasma membrane|
|retrograde transport, endosome to Golgi|
|post-Golgi vesicle-mediated transport|
|cytosolic transport|
|early endosome membrane|
|protein localization to plasma membrane|
|endosome membrane|
|positive regulation of protein catabolic process|
|endosomal transport|
|protein localization to cell periphery|
|early endosome|
|establishment of protein localization to membrane|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|protein localization to membrane|
|protein heterodimerization activity|
|protein-containing complex|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|molecular function|
|Golgi apparatus|
|intracellular protein transport|
|regulation of catabolic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.92|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.87|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.74|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.8|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.84|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.86|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7700
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGA1 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>