======= GGT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGT1
  * **<color #00a2e8>Official Name</color>**: gamma-glutamyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2678|2678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19440|P19440]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612346|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive. {ECO:0000269|PubMed:20622017, ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:7673200, ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045, ECO:0000269|PubMed:8827453}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G glu transpept|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leukotriene-C(4) hydrolase|
|cysteine biosynthetic process|
|peptidyltransferase activity|
|hypoglycin A gamma-glutamyl transpeptidase activity|
|peptide modification|
|leukotriene C4 gamma-glutamyl transferase activity|
|glutathione hydrolase activity|
|glutathione catabolic process|
|leukotriene D4 metabolic process|
|leukotriene D4 biosynthetic process|
|cysteine metabolic process|
|glutathione biosynthetic process|
|nonribosomal peptide biosynthetic process|
|serine family amino acid biosynthetic process|
|sulfur amino acid biosynthetic process|
|leukotriene biosynthetic process|
|peptide catabolic process|
|cellular modified amino acid catabolic process|
|glutamate metabolic process|
|leukotriene metabolic process|
|sulfur amino acid metabolic process|
|zymogen activation|
|serine family amino acid metabolic process|
|icosanoid biosynthetic process|
|cellular modified amino acid biosynthetic process|
|glutathione metabolic process|
|sulfur compound catabolic process|
|cofactor catabolic process|
|alpha-amino acid biosynthetic process|
|glutamine family amino acid metabolic process|
|cellular amino acid biosynthetic process|
|fatty acid derivative biosynthetic process|
|dicarboxylic acid metabolic process|
|icosanoid metabolic process|
|xenobiotic metabolic process|
|response to estradiol|
|protein processing|
|fatty acid derivative metabolic process|
|sulfur compound biosynthetic process|
|cellular response to xenobiotic stimulus|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|protein maturation|
|response to tumor necrosis factor|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|fatty acid metabolic process|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|sulfur compound metabolic process|
|translation|
|peptide biosynthetic process|
|cofactor metabolic process|
|drug metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|spermatogenesis|
|male gamete generation|
|small molecule biosynthetic process|
|response to bacterium|
|gamete generation|
|regulation of defense response|
|cellular amide metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|response to cytokine|
|lipid metabolic process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGT1 Expression in NALM6 Cells: 0.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>