======= GIPR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GIPR
  * **<color #00a2e8>Official Name</color>**: gastric inhibitory polypeptide receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2696|2696]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48546|P48546]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GIPR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GIPR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137241|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gastric inhibitory peptide receptor activity|
|gastric inhibitory peptide signaling pathway|
|desensitization of G protein-coupled receptor signaling pathway|
|negative adaptation of signaling pathway|
|adaptation of signaling pathway|
|positive regulation of cAMP-mediated signaling|
|endocrine pancreas development|
|activation of adenylate cyclase activity|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|negative regulation of G protein-coupled receptor signaling pathway|
|response to axon injury|
|regulation of cAMP-mediated signaling|
|pancreas development|
|positive regulation of insulin secretion|
|response to fatty acid|
|positive regulation of peptide hormone secretion|
|endocrine system development|
|positive regulation of hormone secretion|
|transmembrane signaling receptor activity|
|response to glucose|
|response to hexose|
|regulation of G protein-coupled receptor signaling pathway|
|response to monosaccharide|
|response to calcium ion|
|response to carbohydrate|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|response to nutrient|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|regulation of cytosolic calcium ion concentration|
|response to acid chemical|
|response to metal ion|
|positive regulation of secretion by cell|
|generation of precursor metabolites and energy|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|response to inorganic substance|
|cellular metal ion homeostasis|
|response to wounding|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|response to lipid|
|cellular homeostasis|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|chemical homeostasis|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.07|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|2.09|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3836
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GIPR Expression in NALM6 Cells: 2.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>