======= GJA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GJA5
  * **<color #00a2e8>Official Name</color>**: gap junction protein alpha 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2702|2702]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36382|P36382]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GJA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GJA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/121013|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Connexin CCC|
|Connexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling|
|vasomotion|
|gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling|
|atrial cardiac muscle cell to AV node cell communication by electrical coupling|
|gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling|
|regulation of Purkinje myocyte action potential|
|bundle of His cell to Purkinje myocyte communication by electrical coupling|
|gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling|
|atrial ventricular junction remodeling|
|positive regulation of cell communication by chemical coupling|
|regulation of bundle of His cell action potential|
|regulation of cell communication by chemical coupling|
|SA node cell to atrial cardiac muscle cell communication by electrical coupling|
|gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling|
|foramen ovale closure|
|pulmonary valve formation|
|regulation of AV node cell action potential|
|cell communication by chemical coupling|
|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling|
|gap junction channel activity involved in cardiac conduction electrical coupling|
|AV node cell to bundle of His cell communication by electrical coupling|
|negative regulation of glomerular filtration|
|regulation of renin secretion into blood stream|
|regulation of membrane depolarization during cardiac muscle cell action potential|
|connexin binding|
|septum primum development|
|gap junction hemi-channel activity|
|regulation of atrial cardiac muscle cell action potential|
|Purkinje myocyte to ventricular cardiac muscle cell communication|
|regulation of membrane depolarization during action potential|
|gap junction assembly|
|regulation of ventricular cardiac muscle cell membrane depolarization|
|regulation of atrial cardiac muscle cell membrane depolarization|
|SA node cell action potential|
|SA node cell to atrial cardiac muscle cell signaling|
|SA node cell to atrial cardiac muscle cell communication|
|mitral valve development|
|regulation of glomerular filtration|
|AV node cell to bundle of His cell communication|
|cardiac conduction system development|
|bundle of His cell to Purkinje myocyte communication|
|heart valve formation|
|atrial cardiac muscle cell to AV node cell communication|
|atrial septum morphogenesis|
|renal system process involved in regulation of blood volume|
|cell communication by electrical coupling involved in cardiac conduction|
|gap junction|
|pulmonary valve morphogenesis|
|cell communication by electrical coupling|
|atrial septum development|
|connexin complex|
|pulmonary valve development|
|ventricular cardiac muscle cell action potential|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|renal system process involved in regulation of systemic arterial blood pressure|
|atrioventricular valve development|
|regulation of cardiac muscle cell membrane repolarization|
|cell-cell signaling involved in cardiac conduction|
|regulation of cardiac muscle cell action potential|
|cardiac atrium morphogenesis|
|positive regulation of vasoconstriction|
|disordered domain specific binding|
|regulation of membrane repolarization|
|regulation of renal system process|
|cardiac atrium development|
|semi-lunar valve development|
|regulation of cardiac muscle cell contraction|
|regulation of heart rate by cardiac conduction|
|cardiac muscle cell action potential involved in contraction|
|ventricular septum morphogenesis|
|regulation of actin filament-based movement|
|cardiac muscle cell contraction|
|regulation of endocrine process|
|regulation of membrane depolarization|
|cell communication involved in cardiac conduction|
|intercalated disc|
|negative regulation of blood pressure|
|regulation of action potential|
|cardiac muscle cell action potential|
|heart valve morphogenesis|
|regulation of vasoconstriction|
|positive regulation of blood vessel diameter|
|artery morphogenesis|
|heart valve development|
|regulation of cardiac conduction|
|positive regulation of blood circulation|
|ventricular septum development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|embryonic heart tube development|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|artery development|
|heart contraction|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of systemic arterial blood pressure|
|action potential|
|endothelium development|
|regulation of heart rate|
|cell projection|
|heart process|
|tissue remodeling|
|cell-cell junction assembly|
|striated muscle contraction|
|cardiac septum development|
|actin filament-based movement|
|renal system process|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|multicellular organismal signaling|
|cell-cell junction organization|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|appendage morphogenesis|
|limb morphogenesis|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|potassium ion transport|
|cell junction assembly|
|vascular process in circulatory system|
|cardiac chamber development|
|appendage development|
|limb development|
|regulation of blood pressure|
|cell junction organization|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle contraction|
|heart morphogenesis|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle tissue development|
|muscle system process|
|angiogenesis|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|blood vessel morphogenesis|
|regulation of membrane potential|
|embryonic organ development|
|regulation of protein secretion|
|regulation of ion transmembrane transport|
|blood vessel development|
|skeletal system development|
|regulation of peptide secretion|
|regulation of body fluid levels|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|protein complex oligomerization|
|heart development|
|regulation of transmembrane transport|
|embryonic morphogenesis|
|actin filament-based process|
|regulation of system process|
|metal ion transport|
|tube morphogenesis|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|regulation of cellular component movement|
|regulation of protein localization|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|homeostatic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10135
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GJA5 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>