======= GK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GK
  * **<color #00a2e8>Official Name</color>**: glycerol kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2710|2710]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32189|P32189]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300474|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key enzyme in the regulation of glycerol uptake and metabolism.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGGY C|
|FGGY N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycerol kinase activity|
|glycerol-3-phosphate biosynthetic process|
|glycerol catabolic process|
|alditol catabolic process|
|glycerol-3-phosphate metabolic process|
|alditol phosphate metabolic process|
|triglyceride biosynthetic process|
|glycerol metabolic process|
|acylglycerol biosynthetic process|
|neutral lipid biosynthetic process|
|alditol metabolic process|
|polyol catabolic process|
|cellular carbohydrate catabolic process|
|alcohol catabolic process|
|triglyceride metabolic process|
|organic hydroxy compound catabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|polyol metabolic process|
|carbohydrate catabolic process|
|mitochondrial outer membrane|
|cellular carbohydrate metabolic process|
|glycerolipid biosynthetic process|
|alcohol metabolic process|
|glycerolipid metabolic process|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|mitochondrion|
|phosphorylation|
|ATP binding|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GK Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>