======= GLE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLE1
  * **<color #00a2e8>Official Name</color>**: GLE1 RNA export mediator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2733|2733]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53GS7|Q53GS7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603371|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GLE1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol hexakisphosphate binding|
|nuclear pore cytoplasmic filaments|
|regulation of translational termination|
|poly(A)+ mRNA export from nucleus|
|translation initiation factor binding|
|nuclear pore|
|regulation of translational initiation|
|phospholipid binding|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|regulation of protein complex disassembly|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of translation|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|nucleolus|
|intracellular protein transport|
|identical protein binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.46|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.3|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.27|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.19|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.17|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.83|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.8|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.74|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.75|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.76|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.81|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.82|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.88|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.9|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.9|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.91|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.92|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.97|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.02|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.08|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.11|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.11|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.18|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 88/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|6/28|
|bone|3/26|
|breast|0/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|3/20|
|lung|15/75|
|lymphocyte|1/16|
|ovary|9/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1150
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLE1 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>