======= GLI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLI1
  * **<color #00a2e8>Official Name</color>**: GLI family zinc finger 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2735|2735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08151|P08151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'- GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:8378770, ECO:0000305}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|notochord regression|
|ventral midline development|
|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|
|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|
|positive regulation of cerebellar granule cell precursor proliferation|
|regulation of cerebellar granule cell precursor proliferation|
|notochord morphogenesis|
|anatomical structure regression|
|regulation of hepatocyte proliferation|
|notochord development|
|positive regulation of cardiac muscle cell proliferation|
|cerebellar cortex morphogenesis|
|liver regeneration|
|proximal/distal pattern formation|
|positive regulation of smoothened signaling pathway|
|positive regulation of cardiac muscle tissue growth|
|ciliary base|
|positive regulation of DNA replication|
|positive regulation of heart growth|
|cerebellum morphogenesis|
|regulation of cardiac muscle cell proliferation|
|hindbrain morphogenesis|
|prostate gland development|
|pituitary gland development|
|positive regulation of cardiac muscle tissue development|
|ciliary tip|
|cerebellar cortex development|
|positive regulation of cell cycle G1/S phase transition|
|positive regulation of organ growth|
|digestive tract morphogenesis|
|positive regulation of neural precursor cell proliferation|
|regulation of cardiac muscle tissue growth|
|regulation of heart growth|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|smoothened signaling pathway|
|animal organ regeneration|
|diencephalon development|
|regulation of smoothened signaling pathway|
|regulation of cardiac muscle tissue development|
|dorsal/ventral pattern formation|
|regulation of neural precursor cell proliferation|
|canonical Wnt signaling pathway|
|regulation of organ growth|
|positive regulation of cell cycle phase transition|
|cerebellum development|
|axoneme|
|regulation of DNA replication|
|metencephalon development|
|regulation of osteoblast differentiation|
|endocrine system development|
|liver development|
|osteoblast differentiation|
|hepaticobiliary system development|
|digestive tract development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|digestive system development|
|hindbrain development|
|regeneration|
|regulation of cell cycle G1/S phase transition|
|lung development|
|positive regulation of developmental growth|
|respiratory tube development|
|negative regulation of canonical Wnt signaling pathway|
|regulation of ossification|
|respiratory system development|
|negative regulation of Wnt signaling pathway|
|transcription regulatory region DNA binding|
|microtubule binding|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|ossification|
|regulation of canonical Wnt signaling pathway|
|positive regulation of cell cycle process|
|embryonic organ morphogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|epidermal cell differentiation|
|urogenital system development|
|regulation of developmental growth|
|regionalization|
|regulation of epithelial cell proliferation|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of cell cycle|
|forebrain development|
|chromatin binding|
|gland development|
|epidermis development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|regulation of cell cycle phase transition|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of nervous system development|
|spermatogenesis|
|male gamete generation|
|embryonic morphogenesis|
|response to wounding|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|epithelial cell differentiation|
|gamete generation|
|brain development|
|regulation of cell cycle process|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4909
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLI1 Expression in NALM6 Cells: 1.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>