======= GLRB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLRB
  * **<color #00a2e8>Official Name</color>**: glycine receptor beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2743|2743]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48167|P48167]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLRB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLRB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). {ECO:0000269|PubMed:11929858, ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:23238346, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:8717357}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellularly glycine-gated ion channel activity|
|glycine-gated chloride channel complex|
|gamma-aminobutyric acid receptor clustering|
|extracellularly glycine-gated chloride channel activity|
|synaptic transmission, glycinergic|
|glycinergic synapse|
|righting reflex|
|neurotransmitter-gated ion channel clustering|
|glycine binding|
|reflex|
|acrosome reaction|
|startle response|
|postsynaptic membrane organization|
|adult walking behavior|
|walking behavior|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|receptor clustering|
|extracellular ligand-gated ion channel activity|
|chloride channel activity|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|GABA-ergic synapse|
|adult locomotory behavior|
|localization within membrane|
|postsynapse organization|
|chloride transmembrane transport|
|regulation of postsynaptic membrane potential|
|chloride transport|
|neuropeptide signaling pathway|
|protein heterooligomerization|
|neuromuscular process|
|inorganic anion transmembrane transport|
|response to amino acid|
|transmembrane signaling receptor activity|
|single fertilization|
|adult behavior|
|inorganic anion transport|
|fertilization|
|locomotory behavior|
|postsynaptic membrane|
|visual perception|
|sensory perception of light stimulus|
|synapse|
|synapse organization|
|anion transmembrane transport|
|neuron projection|
|response to acid chemical|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|protein complex oligomerization|
|cell junction|
|behavior|
|anion transport|
|inorganic ion transmembrane transport|
|sexual reproduction|
|membrane organization|
|ion transmembrane transport|
|sensory perception|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to nitrogen compound|
|cell-cell signaling|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLRB Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>