======= GLRX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLRX2
  * **<color #00a2e8>Official Name</color>**: glutaredoxin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51022|51022]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS18|Q9NS18]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLRX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLRX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:14676218, ECO:0000269|PubMed:15328416, ECO:0000269|PubMed:15649413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glutaredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arsenate reductase (glutaredoxin) activity|
|glutathione disulfide oxidoreductase activity|
|DNA protection|
|response to redox state|
|cellular response to oxygen radical|
|cellular response to superoxide|
|response to superoxide|
|response to oxygen radical|
|protein disulfide isomerase activity|
|protein disulfide oxidoreductase activity|
|2 iron, 2 sulfur cluster binding|
|glutathione metabolic process|
|cell redox homeostasis|
|electron transfer activity|
|response to hydrogen peroxide|
|cellular response to reactive oxygen species|
|response to temperature stimulus|
|electron transport chain|
|response to reactive oxygen species|
|cellular modified amino acid metabolic process|
|cellular response to oxidative stress|
|cellular response to extracellular stimulus|
|aging|
|response to antibiotic|
|cellular response to external stimulus|
|sulfur compound metabolic process|
|mitochondrial matrix|
|neuronal cell body|
|response to oxidative stress|
|dendrite|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|response to toxic substance|
|peptide metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|intracellular membrane-bounded organelle|
|DNA metabolic process|
|cellular amide metabolic process|
|cellular homeostasis|
|apoptotic process|
|oxidation-reduction process|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|response to abiotic stimulus|
|mitochondrion|
|response to oxygen-containing compound|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-2.53|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.77|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.94|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11354
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLRX2 Expression in NALM6 Cells: 2.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>