======= GLRX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLRX5
  * **<color #00a2e8>Official Name</color>**: glutaredoxin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51218|51218]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SX6|Q86SX6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLRX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLRX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609588|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q80Y14, ECO:0000269|PubMed:20364084, ECO:0000269|PubMed:24334290}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glutaredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutathione disulfide oxidoreductase activity|
|protein lipoylation|
|protein-cofactor linkage|
|2 iron, 2 sulfur cluster binding|
|protein disulfide oxidoreductase activity|
|cell redox homeostasis|
|electron transfer activity|
|electron transport chain|
|protein maturation|
|peptidyl-lysine modification|
|mitochondrial matrix|
|neuronal cell body|
|dendrite|
|generation of precursor metabolites and energy|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|peptidyl-amino acid modification|
|cellular homeostasis|
|oxidation-reduction process|
|mitochondrion|
|homeostatic process|
|small molecule metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.27|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.24|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.83|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.75|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.74|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.75|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.75|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.78|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.8|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.89|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.92|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.93|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.93|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.96|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.97|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.01|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.02|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.03|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.06|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.07|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.09|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.09|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.1|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.15|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.27|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.29|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.31|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.32|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.33|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.34|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.36|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.4|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.49|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.51|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.67|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.89|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.91|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.91|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.3|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.65|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.89|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|7.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:iba57|IBA57]]|0.701|
|[[:human genes:n:nfu1|NFU1]]|0.661|
|[[:human genes:i:isca2|ISCA2]]|0.6|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.577|
|[[:human genes:s:sucla2|SUCLA2]]|0.575|
|[[:human genes:s:suclg1|SUCLG1]]|0.569|
|[[:human genes:m:mipep|MIPEP]]|0.556|
|[[:human genes:s:slc25a26|SLC25A26]]|0.555|
|[[:human genes:n:ndufb9|NDUFB9]]|0.537|
|[[:human genes:a:acad9|ACAD9]]|0.527|
|[[:human genes:n:ndufb11|NDUFB11]]|0.524|
|[[:human genes:n:nubpl|NUBPL]]|0.517|
|[[:human genes:h:hmbs|HMBS]]|0.502|
|[[:human genes:a:abhd11|ABHD11]]|0.498|
|[[:human genes:n:ndufa3|NDUFA3]]|0.498|
|[[:human genes:m:mcat|MCAT]]|0.494|
|[[:human genes:n:ndufa1|NDUFA1]]|0.494|
|[[:human genes:n:ndufs2|NDUFS2]]|0.488|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.484|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.481|
|[[:human genes:c:c17orf89|C17orf89]]|0.469|
|[[:human genes:c:c12orf65|C12orf65]]|0.467|
|[[:human genes:r:rbfa|RBFA]]|0.466|
|[[:human genes:n:ndufa11|NDUFA11]]|0.466|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.465|
|[[:human genes:t:timm17a|TIMM17A]]|0.464|
|[[:human genes:m:mrpl21|MRPL21]]|0.463|
|[[:human genes:t:tpk1|TPK1]]|0.462|
|[[:human genes:m:mto1|MTO1]]|0.461|
|[[:human genes:r:rpusd3|RPUSD3]]|0.46|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.459|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.459|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.458|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.458|
|[[:human genes:m:mtg1|MTG1]]|0.456|
|[[:human genes:e:ecsit|ECSIT]]|0.454|
|[[:human genes:n:ndufc1|NDUFC1]]|0.449|
|[[:human genes:n:ndufb5|NDUFB5]]|0.446|
|[[:human genes:m:mrpl23|MRPL23]]|0.446|
|[[:human genes:g:grsf1|GRSF1]]|0.444|
|[[:human genes:m:mrps21|MRPS21]]|0.443|
|[[:human genes:n:ndufa2|NDUFA2]]|0.441|
|[[:human genes:m:mrps5|MRPS5]]|0.441|
|[[:human genes:n:ndufc2|NDUFC2]]|0.44|
|[[:human genes:a:alas1|ALAS1]]|0.439|
|[[:human genes:m:mrps34|MRPS34]]|0.437|
|[[:human genes:n:ndufb7|NDUFB7]]|0.437|
|[[:human genes:w:wbscr16|WBSCR16]]|0.436|
|[[:human genes:f:fars2|FARS2]]|0.436|
|[[:human genes:n:ndufv1|NDUFV1]]|0.436|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.435|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.434|
|[[:human genes:m:mecr|MECR]]|0.434|
|[[:human genes:g:gfm2|GFM2]]|0.432|
|[[:human genes:l:lipt2|LIPT2]]|0.431|
|[[:human genes:m:mrps12|MRPS12]]|0.43|
|[[:human genes:m:mrpl47|MRPL47]]|0.429|
|[[:human genes:c:coq3|COQ3]]|0.428|
|[[:human genes:p:pet112|PET112]]|0.427|
|[[:human genes:t:tomm20|TOMM20]]|0.427|
|[[:human genes:n:ndufb6|NDUFB6]]|0.426|
|[[:human genes:n:ndufb2|NDUFB2]]|0.424|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.424|
|[[:human genes:c:chchd1|CHCHD1]]|0.424|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.423|
|[[:human genes:n:ndufa10|NDUFA10]]|0.422|
|[[:human genes:m:mrps16|MRPS16]]|0.422|
|[[:human genes:r:rpusd4|RPUSD4]]|0.421|
|[[:human genes:m:mrps22|MRPS22]]|0.42|
|[[:human genes:c:coq2|COQ2]]|0.418|
|[[:human genes:n:ndufa6|NDUFA6]]|0.417|
|[[:human genes:y:yars2|YARS2]]|0.417|
|[[:human genes:m:mrps33|MRPS33]]|0.414|
|[[:human genes:i:ict1|ICT1]]|0.412|
|[[:human genes:m:mrps6|MRPS6]]|0.412|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.411|
|[[:human genes:i:isca1|ISCA1]]|0.408|
|[[:human genes:t:tefm|TEFM]]|0.406|
|[[:human genes:m:mrpl22|MRPL22]]|0.406|
|[[:human genes:g:gfm1|GFM1]]|0.405|
|[[:human genes:p:pdxk|PDXK]]|0.404|
|[[:human genes:f:fech|FECH]]|0.402|
|[[:human genes:p:pdss1|PDSS1]]|0.402|
|[[:human genes:m:mrps26|MRPS26]]|0.401|
|[[:human genes:t:trub2|TRUB2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 60/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|3/26|
|breast|5/33|
|central nervous system|5/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|1/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLRX5 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>