======= GMPS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GMPS
  * **<color #00a2e8>Official Name</color>**: guanine monophosphate synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8833|8833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49915|P49915]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GMPS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GMPS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GATase|
|ExsB|
|Peptidase C26|
|NAD synthase|
|GMP synt C|
|Asn synthase|
|tRNA Me trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GMP synthase (glutamine-hydrolyzing) activity|
|GMP synthase activity|
|GMP biosynthetic process|
|pyrophosphatase activity|
|purine nucleobase biosynthetic process|
|guanosine-containing compound biosynthetic process|
|GMP metabolic process|
|purine ribonucleoside monophosphate biosynthetic process|
|purine nucleoside monophosphate biosynthetic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|purine nucleoside biosynthetic process|
|glutamine metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside biosynthetic process|
|guanosine-containing compound metabolic process|
|glycosyl compound biosynthetic process|
|nucleobase metabolic process|
|nucleoside monophosphate biosynthetic process|
|pigment biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|purine ribonucleoside metabolic process|
|pigment metabolic process|
|purine nucleoside metabolic process|
|glutamine family amino acid metabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|alpha-amino acid metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.75|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.72|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.74|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.74|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 382/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|19/28|
|bone|9/26|
|breast|26/33|
|central nervous system|7/56|
|cervix|3/4|
|colorectal|8/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|13/21|
|liver|7/20|
|lung|42/75|
|lymphocyte|12/16|
|ovary|13/26|
|pancreas|19/24|
|peripheral nervous system|4/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GMPS Expression in NALM6 Cells: 7.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>