======= GNAO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNAO1
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha o1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2775|2775]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09471|P09471]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNAO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNAO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139311|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|G-alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mu-type opioid receptor binding|
|G protein-coupled serotonin receptor binding|
|corticotropin-releasing hormone receptor 1 binding|
|GTPase activating protein binding|
|G-protein beta/gamma-subunit complex binding|
|heterotrimeric G-protein complex|
|myelin sheath|
|response to isoquinoline alkaloid|
|response to morphine|
|dopamine receptor signaling pathway|
|Wnt signaling pathway, calcium modulating pathway|
|negative regulation of calcium ion transport|
|G protein-coupled receptor binding|
|cell body|
|response to anesthetic|
|odontogenesis of dentin-containing tooth|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to monoamine|
|response to catecholamine|
|response to alkaloid|
|response to hydrogen peroxide|
|odontogenesis|
|cellular response to ammonium ion|
|non-canonical Wnt signaling pathway|
|negative regulation of ion transport|
|response to ammonium ion|
|response to reactive oxygen species|
|locomotory behavior|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|protein folding|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|muscle contraction|
|aging|
|regulation of blood circulation|
|muscle system process|
|response to xenobiotic stimulus|
|response to antibiotic|
|GTPase activity|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of metal ion transport|
|response to oxidative stress|
|forebrain development|
|GTP binding|
|cellular response to drug|
|positive regulation of GTPase activity|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of GTPase activity|
|negative regulation of transport|
|response to toxic substance|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of ion transport|
|brain development|
|positive regulation of hydrolase activity|
|head development|
|neuron development|
|response to organic cyclic compound|
|animal organ morphogenesis|
|central nervous system development|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|neurogenesis|
|cell development|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3954
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNAO1 Expression in NALM6 Cells: 0.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>