======= GNB1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNB1L
  * **<color #00a2e8>Official Name</color>**: G protein subunit beta 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54584|54584]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYB4|Q9BYB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNB1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNB1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610778|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|social behavior|
|intraspecies interaction between organisms|
|cytoplasmic side of plasma membrane|
|multi-organism behavior|
|behavior|
|molecular function|
|G protein-coupled receptor signaling pathway|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.93|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.87|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.82|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.82|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.78|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.76|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.76|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.74|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.73|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.71|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.7|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.7|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.7|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.73|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.86|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.04|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.1|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.27|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.38|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.39|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.87|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tti2|TTI2]]|0.713|
|[[:human genes:t:tti1|TTI1]]|0.679|
|[[:human genes:t:telo2|TELO2]]|0.657|
|[[:human genes:m:med16|MED16]]|0.648|
|[[:human genes:r:rnmt|RNMT]]|0.64|
|[[:human genes:r:rptor|RPTOR]]|0.64|
|[[:human genes:g:gfpt1|GFPT1]]|0.629|
|[[:human genes:c:ccdc101|CCDC101]]|0.622|
|[[:human genes:r:rtcb|RTCB]]|0.618|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.616|
|[[:human genes:p:pmm2|PMM2]]|0.601|
|[[:human genes:t:thg1l|THG1L]]|0.597|
|[[:human genes:g:gmppb|GMPPB]]|0.596|
|[[:human genes:d:dpagt1|DPAGT1]]|0.59|
|[[:human genes:r:rpp21|RPP21]]|0.588|
|[[:human genes:a:alg1|ALG1]]|0.587|
|[[:human genes:e:exoc4|EXOC4]]|0.58|
|[[:human genes:m:mllt1|MLLT1]]|0.578|
|[[:human genes:a:alg13|ALG13]]|0.578|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.565|
|[[:human genes:p:polr3h|POLR3H]]|0.564|
|[[:human genes:t:tsen54|TSEN54]]|0.563|
|[[:human genes:a:alg2|ALG2]]|0.56|
|[[:human genes:d:dohh|DOHH]]|0.56|
|[[:human genes:o:osgep|OSGEP]]|0.549|
|[[:human genes:u:uap1|UAP1]]|0.546|
|[[:human genes:m:mtor|MTOR]]|0.546|
|[[:human genes:m:med23|MED23]]|0.544|
|[[:human genes:w:wdr24|WDR24]]|0.538|
|[[:human genes:p:ppp4c|PPP4C]]|0.537|
|[[:human genes:u:uhrf1|UHRF1]]|0.536|
|[[:human genes:a:aars|AARS]]|0.536|
|[[:human genes:c:cbfb|CBFB]]|0.535|
|[[:human genes:c:csnk2b|CSNK2B]]|0.529|
|[[:human genes:a:adsl|ADSL]]|0.528|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.527|
|[[:human genes:r:rpn1|RPN1]]|0.527|
|[[:human genes:z:znf259|ZNF259]]|0.525|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.522|
|[[:human genes:s:snapc5|SNAPC5]]|0.52|
|[[:human genes:t:trmt5|TRMT5]]|0.52|
|[[:human genes:v:vmp1|VMP1]]|0.519|
|[[:human genes:n:nae1|NAE1]]|0.516|
|[[:human genes:m:mapk14|MAPK14]]|0.515|
|[[:human genes:s:srp14|SRP14]]|0.512|
|[[:human genes:d:dad1|DAD1]]|0.51|
|[[:human genes:d:ddx20|DDX20]]|0.509|
|[[:human genes:p:polr3b|POLR3B]]|0.508|
|[[:human genes:s:snf8|SNF8]]|0.507|
|[[:human genes:d:ddost|DDOST]]|0.505|
|[[:human genes:c:cct7|CCT7]]|0.503|
|[[:human genes:e:eif4e|EIF4E]]|0.501|
|[[:human genes:t:tsen34|TSEN34]]|0.5|
|[[:human genes:h:hspd1|HSPD1]]|0.498|
|[[:human genes:p:pelo|PELO]]|0.498|
|[[:human genes:e:eprs|EPRS]]|0.498|
|[[:human genes:y:yars|YARS]]|0.493|
|[[:human genes:t:trnt1|TRNT1]]|0.493|
|[[:human genes:f:fnta|FNTA]]|0.492|
|[[:human genes:l:lsm11|LSM11]]|0.491|
|[[:human genes:e:ercc2|ERCC2]]|0.491|
|[[:human genes:r:rbm14|RBM14]]|0.49|
|[[:human genes:t:taz|TAZ]]|0.49|
|[[:human genes:d:dhps|DHPS]]|0.49|
|[[:human genes:c:crcp|CRCP]]|0.486|
|[[:human genes:h:hars|HARS]]|0.48|
|[[:human genes:u:ube2g2|UBE2G2]]|0.477|
|[[:human genes:g:gemin8|GEMIN8]]|0.476|
|[[:human genes:a:atxn10|ATXN10]]|0.476|
|[[:human genes:v:vezt|VEZT]]|0.474|
|[[:human genes:c:cdipt|CDIPT]]|0.473|
|[[:human genes:t:thoc6|THOC6]]|0.473|
|[[:human genes:g:gpn2|GPN2]]|0.473|
|[[:human genes:d:dr1|DR1]]|0.473|
|[[:human genes:s:seh1l|SEH1L]]|0.473|
|[[:human genes:t:tamm41|TAMM41]]|0.471|
|[[:human genes:v:vhl|VHL]]|0.47|
|[[:human genes:a:atp5j|ATP5J]]|0.469|
|[[:human genes:s:srp72|SRP72]]|0.469|
|[[:human genes:p:pam16|PAM16]]|0.469|
|[[:human genes:h:haus8|HAUS8]]|0.468|
|[[:human genes:p:ppcs|PPCS]]|0.468|
|[[:human genes:u:uxt|UXT]]|0.466|
|[[:human genes:t:triap1|TRIAP1]]|0.466|
|[[:human genes:m:mars|MARS]]|0.465|
|[[:human genes:b:bub3|BUB3]]|0.464|
|[[:human genes:t:tbca|TBCA]]|0.463|
|[[:human genes:a:atf7ip|ATF7IP]]|0.463|
|[[:human genes:p:pax5|PAX5]]|0.461|
|[[:human genes:t:tle4|TLE4]]|0.459|
|[[:human genes:a:alg5|ALG5]]|0.459|
|[[:human genes:d:dhx29|DHX29]]|0.458|
|[[:human genes:o:otud5|OTUD5]]|0.458|
|[[:human genes:r:rpe|RPE]]|0.457|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.457|
|[[:human genes:t:tmem41b|TMEM41B]]|0.457|
|[[:human genes:v:vrk1|VRK1]]|0.453|
|[[:human genes:o:oraov1|ORAOV1]]|0.452|
|[[:human genes:n:nars|NARS]]|0.449|
|[[:human genes:t:tbcb|TBCB]]|0.449|
|[[:human genes:w:wdr59|WDR59]]|0.448|
|[[:human genes:t:tsen2|TSEN2]]|0.448|
|[[:human genes:r:rad1|RAD1]]|0.447|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.447|
|[[:human genes:d:dhdds|DHDDS]]|0.444|
|[[:human genes:d:ddx6|DDX6]]|0.444|
|[[:human genes:s:spcs3|SPCS3]]|0.442|
|[[:human genes:n:nsmce1|NSMCE1]]|0.441|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.436|
|[[:human genes:d:ddx1|DDX1]]|0.434|
|[[:human genes:s:slc35b1|SLC35B1]]|0.431|
|[[:human genes:w:wdr82|WDR82]]|0.43|
|[[:human genes:z:zbtb11|ZBTB11]]|0.43|
|[[:human genes:a:alg14|ALG14]]|0.427|
|[[:human genes:e:elac2|ELAC2]]|0.427|
|[[:human genes:x:xpo5|XPO5]]|0.425|
|[[:human genes:t:thoc3|THOC3]]|0.425|
|[[:human genes:c:c21orf59|C21orf59]]|0.422|
|[[:human genes:s:srp68|SRP68]]|0.421|
|[[:human genes:t:ten1|TEN1]]|0.42|
|[[:human genes:t:tp53rk|TP53RK]]|0.42|
|[[:human genes:d:dctn5|DCTN5]]|0.418|
|[[:human genes:b:bap1|BAP1]]|0.417|
|[[:human genes:e:exoc3|EXOC3]]|0.417|
|[[:human genes:r:rft1|RFT1]]|0.417|
|[[:human genes:w:wdr1|WDR1]]|0.413|
|[[:human genes:g:gtf3a|GTF3A]]|0.412|
|[[:human genes:l:lsmd1|LSMD1]]|0.412|
|[[:human genes:m:mad2l1|MAD2L1]]|0.409|
|[[:human genes:a:atp5b|ATP5B]]|0.408|
|[[:human genes:m:med25|MED25]]|0.407|
|[[:human genes:z:zrsr2|ZRSR2]]|0.406|
|[[:human genes:t:tada1|TADA1]]|0.406|
|[[:human genes:w:wdr92|WDR92]]|0.405|
|[[:human genes:g:gemin6|GEMIN6]]|0.405|
|[[:human genes:m:med4|MED4]]|0.404|
|[[:human genes:m:meaf6|MEAF6]]|0.403|
|[[:human genes:t:tprkb|TPRKB]]|0.403|
|[[:human genes:e:eif3f|EIF3F]]|0.401|
|[[:human genes:d:dctn6|DCTN6]]|0.401|
|[[:human genes:u:uba3|UBA3]]|0.401|
|[[:human genes:w:wars|WARS]]|0.401|
|[[:human genes:a:atp5o|ATP5O]]|0.401|
|[[:human genes:s:slc25a19|SLC25A19]]|0.4|
|[[:human genes:a:actr10|ACTR10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 287/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|6/28|
|bone|12/26|
|breast|16/33|
|central nervous system|29/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|6/21|
|liver|8/20|
|lung|34/75|
|lymphocyte|1/16|
|ovary|11/26|
|pancreas|14/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 855
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNB1L Expression in NALM6 Cells: 3.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>