======= GNPAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNPAT
  * **<color #00a2e8>Official Name</color>**: glyceronephosphate O-acyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8443|8443]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15228|O15228]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNPAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNPAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602744|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyltransferase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycerone-phosphate O-acyltransferase activity|
|glycerol ether biosynthetic process|
|ether biosynthetic process|
|ether lipid biosynthetic process|
|paranodal junction assembly|
|cellular lipid biosynthetic process|
|ether lipid metabolic process|
|glycerol ether metabolic process|
|palmitoyl-CoA hydrolase activity|
|ether metabolic process|
|myelin assembly|
|cerebellum morphogenesis|
|phosphatidic acid biosynthetic process|
|hindbrain morphogenesis|
|phosphatidic acid metabolic process|
|peroxisomal matrix|
|peroxisomal membrane|
|establishment of protein localization to peroxisome|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|response to fatty acid|
|synapse assembly|
|mitochondrial membrane|
|cerebellum development|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|myelination|
|peroxisome|
|axon ensheathment|
|ensheathment of neurons|
|metencephalon development|
|cell-cell junction organization|
|hindbrain development|
|cell junction assembly|
|response to starvation|
|glycerophospholipid biosynthetic process|
|cell junction organization|
|response to nutrient|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|synapse organization|
|glycerophospholipid metabolic process|
|fatty acid metabolic process|
|response to acid chemical|
|protein targeting|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|establishment of protein localization to organelle|
|response to nutrient levels|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|protein localization to organelle|
|brain development|
|head development|
|cellular component morphogenesis|
|membrane organization|
|response to lipid|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|central nervous system development|
|intracellular protein transport|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|lipid metabolic process|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|small molecule metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.84|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.87|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.91|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:agps|AGPS]]|0.496|
|[[:human genes:p:pex1|PEX1]]|0.452|
|[[:human genes:r:rrm1|RRM1]]|0.451|
|[[:human genes:p:polr2j3|POLR2J3]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9692
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNPAT Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>