======= GPBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPBP1
  * **<color #00a2e8>Official Name</color>**: GC-rich promoter binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65056|65056]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WP2|Q86WP2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608412|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.48|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.38|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.22|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.2|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.18|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.07|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.07|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.02|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.01|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.96|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.94|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.92|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.92|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.86|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.86|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.85|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.8|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.72|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.08|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.25|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.3|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9558
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPBP1 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>