======= GPC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPC3
  * **<color #00a2e8>Official Name</color>**: glypican 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2719|2719]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51654|P51654]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300037|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. {ECO:0000269|PubMed:17549790}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glypican|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-dipeptidase inhibitor activity|
|cell proliferation involved in mesonephros development|
|mesenchymal cell proliferation involved in ureteric bud development|
|mesonephric duct morphogenesis|
|cell proliferation involved in metanephros development|
|mesonephric duct development|
|positive regulation of Wnt signaling pathway, planar cell polarity pathway|
|cell proliferation involved in kidney development|
|nephric duct morphogenesis|
|positive regulation of non-canonical Wnt signaling pathway|
|regulation of Wnt signaling pathway, planar cell polarity pathway|
|cell migration involved in gastrulation|
|mesenchymal cell proliferation|
|nephric duct development|
|regulation of non-canonical Wnt signaling pathway|
|embryonic hindlimb morphogenesis|
|negative regulation of smoothened signaling pathway|
|positive regulation of smoothened signaling pathway|
|positive regulation of BMP signaling pathway|
|anchored component of plasma membrane|
|hindlimb morphogenesis|
|positive regulation of glucose import|
|intrinsic component of plasma membrane|
|positive regulation of glucose transmembrane transport|
|osteoclast differentiation|
|branching involved in ureteric bud morphogenesis|
|coronary vasculature development|
|body morphogenesis|
|bone mineralization|
|anterior/posterior axis specification|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of glucose import|
|glycosaminoglycan catabolic process|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|aminoglycan catabolic process|
|nephron morphogenesis|
|renal tubule morphogenesis|
|regulation of glucose transmembrane transport|
|regulation of smoothened signaling pathway|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|kidney morphogenesis|
|axis specification|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|regulation of BMP signaling pathway|
|mesonephros development|
|biomineral tissue development|
|biomineralization|
|lysosomal lumen|
|nephron epithelium development|
|positive regulation of endocytosis|
|Golgi lumen|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|glycosaminoglycan biosynthetic process|
|retinoid metabolic process|
|aminoglycan biosynthetic process|
|diterpenoid metabolic process|
|myeloid leukocyte differentiation|
|regulation of establishment of planar polarity|
|terpenoid metabolic process|
|negative regulation of epithelial cell proliferation|
|nephron development|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|isoprenoid metabolic process|
|positive regulation of canonical Wnt signaling pathway|
|limb morphogenesis|
|appendage morphogenesis|
|glycosaminoglycan metabolic process|
|gastrulation|
|morphogenesis of a branching epithelium|
|aminoglycan metabolic process|
|morphogenesis of a branching structure|
|lung development|
|ameboidal-type cell migration|
|respiratory tube development|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|limb development|
|regulation of morphogenesis of an epithelium|
|appendage development|
|regulation of protein localization to membrane|
|carbohydrate derivative catabolic process|
|respiratory system development|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|negative regulation of Wnt signaling pathway|
|anterior/posterior pattern specification|
|positive regulation of protein catabolic process|
|myeloid cell differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of growth|
|negative regulation of peptidase activity|
|regulation of animal organ morphogenesis|
|ossification|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|urogenital system development|
|leukocyte differentiation|
|regionalization|
|regulation of epithelial cell proliferation|
|negative regulation of proteolysis|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|pattern specification process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|hemopoiesis|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|cell surface|
|carbohydrate derivative biosynthetic process|
|immune system development|
|tube morphogenesis|
|regulation of growth|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|tube development|
|circulatory system development|
|regulation of cellular localization|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|cell migration|
|embryo development|
|positive regulation of transport|
|regulation of catabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|lipid metabolic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|2.27|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPC3 Expression in NALM6 Cells: -2.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>