======= GPD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPD1
  * **<color #00a2e8>Official Name</color>**: glycerol-3-phosphate dehydrogenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2819|2819]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21695|P21695]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAD Gly3P dh C|
|NAD Gly3P dh N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycerol-3-phosphate dehydrogenase (quinone) activity|
|glycerophosphate shuttle|
|glycerol-3-phosphate catabolic process|
|glycerol-3-phosphate dehydrogenase [NAD+] activity|
|glycerol-3-phosphate dehydrogenase complex|
|NADH oxidation|
|glycerol-3-phosphate metabolic process|
|alditol phosphate metabolic process|
|positive regulation of glycolytic process|
|NADH metabolic process|
|NAD binding|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|gluconeogenesis|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|NAD metabolic process|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|cellular response to cAMP|
|cellular ketone metabolic process|
|primary alcohol metabolic process|
|positive regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|regulation of carbohydrate catabolic process|
|response to cAMP|
|respiratory electron transport chain|
|glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|carbohydrate biosynthetic process|
|organophosphate catabolic process|
|response to organophosphorus|
|positive regulation of small molecule metabolic process|
|response to purine-containing compound|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular respiration|
|electron transport chain|
|carbohydrate derivative catabolic process|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|energy derivation by oxidation of organic compounds|
|cellular response to tumor necrosis factor|
|phospholipid biosynthetic process|
|response to tumor necrosis factor|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|positive regulation of cellular catabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|organophosphate biosynthetic process|
|cellular response to organic cyclic compound|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.86|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5321
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPD1 Expression in NALM6 Cells: 1.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>